TABLE 5.
Associations between SLC17A8, TRPV1, TRPV4 and TRPM8 gene polymorphisms and anxiety and depression in migraine patients.
| SNPs/genotypes/genetic models | Anxiety No. (%) | ORadj (95% CI) | p | Depression No. (%) | ORadj (95% CI) | p | ||
|---|---|---|---|---|---|---|---|---|
| No anxiety | Anxiety | No depression | Depression | |||||
| SLC17A8-rs11110359 G>A | ||||||||
| GG | 147 (72.77) | 36 (73.47) | ref | 95 (68.35) | 88 (78.57) | ref | ||
| GA | 51 (25.25) | 12 (24.49) | 0.66 (0.27–1.51) | 0.338 | 41 (29.50) | 22 (19.64) | 0.43 (0.20–0.88) | 0.024 |
| AA | 4 (1.98) | 1 (2.04) | 3.26 (0.15–31.27) | 0.341 | 3 (2.16) | 2 (1.79) | 0.29 (0.02–2.91) | 0.300 |
| Dominant model | 0.74 (0.31–1.64) | 0.464 | 0.42 (0.20–0.84) | 0.016 | ||||
| Recessive model | 0.65 (0.27–1.48) | 0.319 | 0.44 (0.21–0.90) | 0.028 | ||||
| Additive model | 1.54 (0.68–3.77) | 0.319 | 2.28 (1.11–4.82) | 0.028 | ||||
| TRPV1-rs222741 A>G | ||||||||
| AA | 137 (67.82) | 25 (51.02) | ref | 98 (70.50) | 64 (57.14) | ref | ||
| GA | 59 (29.21) | 23 (46.94) | 2.72 (1.26–5.99) | 0.011 | 37 (26.62) | 45 (40.18) | 1.98 (1.02–3.89) | 0.046 |
| GG | 6 (2.97) | 1 (2.04) | 1.67 (0.08–11.99) | 0.659 | 4 (2.88) | 3 (2.68) | 1.12 (0.15–7.19) | 0.909 |
| Dominant model | 0.93 (0.28–3.61) | 0.906 | 0.70 (0.24–2.04) | 0.503 | ||||
| Recessive model | 2.64 (1.24–5.73) | 0.012 | 1.97 (1.02–3.85) | 0.046 | ||||
| Additive model | 0.38 (0.17–0.81) | 0.012 | 0.51 (0.26–0.98) | 0.046 | ||||
| TRPV4-rs3742037 G>A | ||||||||
| GG | 136 (67.33) | 32 (65.31) | ref | 99 (71.22) | 69 (61.61) | ref | ||
| GA | 59 (29.21) | 14 (28.57) | 1.23 (0.54–2.78) | 0.615 | 36 (25.90) | 37 (33.04) | 2.03 (1.02–4.09) | 0.045 |
| AA | 7 (3.47) | 3 (6.12) | 1.15 (0.18–5.92) | 0.877 | 4 (2.88) | 6 (5.36) | 2.06 (0.43–11.10) | 0.373 |
| Dominant model | 1.22 (0.56–2.63) | 0.614 | 2.03 (1.06–3.96) | 0.035 | ||||
| Recessive model | 1.22 (0.54–2.74) | 0.626 | 1.95 (0.99–3.92) | 0.055 | ||||
| Additive model | 0.82 (0.37–1.87) | 0.626 | 0.51 (0.26–1.01) | 0.055 | ||||
| TRPM8-rs17862920 C>T | ||||||||
| CC | 130 (64.36) | 27 (55.10) | ref | 84 (60.43) | 73 (65.18) | ref | ||
| CT | 64 (31.68) | 18 (36.74) | 2.00 (0.87–4.65) | 0.102 | 50 (35.97) | 32 (28.57) | 0.84 (0.42–1.69) | 0.628 |
| TT | 8 (3.96) | 4 (8.16) | 4.72 (0.89–24.14) | 0.060 | 5 (3.60) | 7 (6.25) | 3.98 (0.92–18.96) | 0.070 |
| Dominant model | 0.88 (0.37–2.02) | 0.769 | 0.48 (0.23–0.96) | 0.042 | ||||
| Recessive model | 1.71 (0.76–3.84) | 0.193 | 0.75 (0.38–1.47) | 0.403 | ||||
| Additive model | 0.59 (0.26–1.32) | 0.193 | 1.34 (0.68–2.66) | 0.403 | ||||
| TRPM8-rs10166942 C>T | ||||||||
| CC | 74 (36.63) | 22 (44.90) | ref | 48 (34.53) | 48 (42.86) | ref | ||
| TC | 98 (48.52) | 20 (40.82) | 0.46 (0.20–1.04) | 0.065 | 73 (52.52) | 45 (40.18) | 0.50 (0.25–0.99) | 0.048 |
| TT | 30 (14.85) | 7 (14.29) | 0.99 (0.31–2.92) | 0.989 | 18 (12.95) | 19 (16.96) | 0.95 (0.37–2.42) | 0.909 |
| Dominant model | 0.56 (0.26–1.19) | 0.131 | 0.59 (0.30–1.12) | 0.106 | ||||
| Recessive model | 0.46 (0.21–0.99) | 0.052 | 0.51 (0.27–0.94) | 0.034 | ||||
| Additive model | 2.17 (1.01–4.87) | 0.052 | 1.98 (1.06–3.77) | 0.034 | ||||
| TRPM8-rs7577262 G>A | ||||||||
| GG | 95 (47.03) | 21 (42.86) | ref | 58 (41.73) | 58 (51.79) | ref | ||
| GA | 88 (43.56) | 17 (34.69) | 0.85 (0.37–1.95) | 0.705 | 67 (48.20) | 38 (33.93) | 0.72 (0.36–1.40) | 0.329 |
| AA | 19 (9.41) | 11 (22.45) | 3.41 (1.16–10.01) | 0.025 | 14 (10.07) | 16 (14.29) | 1.47 (0.54–4.10) | 0.450 |
| Dominant model | 0.27 (0.10–0.76) | 0.011 | 0.58 (0.22–1.50) | 0.266 | ||||
| Recessive model | 0.64 (0.29–1.36) | 0.251 | 0.66 (0.35–1.25) | 0.203 | ||||
| Additive model | 1.57 (0.73–3.49) | 0.251 | 1.52 (0.80–2.89) | 0.203 | ||||
Bold type indicates p < 0.05. ORadj (95% CI) adjusted factors: age, sex, BMI, marital status, nationality, educational level, smoking, alcohol, exercise, history of hypertension, history of diabetes, family history of diabetes, family history of migraine, PSQI grade.
SLC17A8, solute carrier family 17 member 8; TRPV1, transient receptor potential cation channel subfamily V member 1; TRPV4, transient receptor potential cation channel subfamily V member 4; TRPM8, transient receptor potential cation channel subfamily M member 8.