TABLE 6.
The relationship between the GRS and migraine susceptibility.
| GRS | Total (N = 851) | T or ORadj (95% CI) | p | Anxiety or depression (N = 281) | T or ORadj (95% CI)* | p | ||
|---|---|---|---|---|---|---|---|---|
| Control (N = 600) | Migraine (N = 251) | Control (N = 158) | Migraine (N = 123) | |||||
| Mean ± SD | 10.91 ± 2.42 | 11.47 ± 2.45 | −3.086 | 0.002 | 11.04 ± 2.31 | 11.22 ± 2.41 | −0.616 | 0.539 |
| Groups, N (%) | ||||||||
| Q1 (4–9) | 164 (27.33) | 51 (20.32) | ref | 36 (22.79) | 30 (24.39) | ref | ||
| Q2 (10–11) | 189 (31.50) | 78 (31.08) | 1.41 (0.90–2.21) | 0.136 | 55 (34.81) | 42 (34.15) | 1.21 (0.60–2.45) | 0.602 |
| Q3 (12–13) | 167 (27.83) | 67 (26.69) | 1.41 (0.89–2.24) | 0.149 | 45 (28.48) | 27 (21.95) | 0.85 (0.40–1.81) | 0.676 |
| Q4 (14–17) | 80 (13.33) | 55 (21.91) | 2.31 (1.39–3.86) | 0.001 | 22 (13.92) | 24 (19.51) | 1.39 (0.61–3.23) | 0.436 |
| p for trend | 0.003 | 0.743 | ||||||
GRS: genetic risk scores. Total of 11 SNPs (rs11110359 and rs11568537 of SLC17A8; GRIK2 rs2227283; SHANK1 rs3745521; rs8065080 and rs222741 of TRPV1; TRPV3 rs7217270; TRPV4 rs3742037; rs17862920, rs10166942 and rs7577262 of TRPM8) were included in the calculation of GRS. ORadj (95% CI) adjusted factors: age, sex, BMI, marital status, nationality, educational level, smoking, alcohol, exercise, history of hypertension, history of diabetes, family history of diabetes, family history of migraine, SAS grade, PHQ9 grade, PSQI grade.
ORadj(95% CI)* adjusted factors did not include SAS grade, PHQ9 grade.