TABLE 7.
The relationship between the GRS and migraine comorbidities of anxiety and depression susceptibility.
| GRS | Migraine (N = 251) | T or ORadj (95% CI) | p | Migraine (N = 251) | T or ORadj (95% CI) | p | ||
|---|---|---|---|---|---|---|---|---|
| No(N = 202) | Anxiety (N = 49) | No(N = 139) | Depression (N = 112) | |||||
| Mean ± SD | 11.59 ± 2.45 | 11.00 ± 2.42 | 1.528 | 0.131 | 11.68 ± 2.47 | 11.22 ± 2.40 | 1.466 | 0.144 |
| Groups, N (%) | ||||||||
| Q1 (4–9) | 37 (18.32) | 14 (28.57) | ref | 23 (16.55) | 28 (25.00) | ref | ||
| Q2 (10–11) | 62 (30.69) | 16 (32.65) | 0.48 (0.17–1.30) | 0.149 | 40 (28.78) | 38 (33.93) | 0.97 (0.40–2.36) | 0.939 |
| Q3 (12–13) | 56 (27.72) | 11 (22.45) | 0.31 (0.11–0.89) | 0.032 | 44 (31.66) | 23 (20.54) | 0.14 (0.19–1.25) | 0.137 |
| Q4 (14–17) | 47 (23.27) | 8 (16.33) | 0.28 (0.08–0.88) | 0.034 | 32 (23.02) | 23 (20.54) | 0.07 (0.15–1.06) | 0.068 |
| p for trend | 0.020 | 0.025 | ||||||
GRS: genetic risk scores. Total of 11 SNPs (rs11110359 and rs11568537 of SLC17A8; GRIK2 rs2227283; SHANK1 rs3745521; rs8065080 and rs222741 of TRPV1; TRPV3 rs7217270; TRPV4 rs3742037; rs17862920, rs10166942 and rs7577262 of TRPM8) were included in the calculation of GRS. ORadj (95% CI) adjusted factors: age, sex, BMI, marital status, nationality, educational level, smoking, alcohol, exercise, history of hypertension, history of diabetes, family history of diabetes, family history of migraine, PSQI grade.