. 2023 May 26;14:1158028. doi: 10.3389/fgene.2023.1158028

TABLE 8.

GMDR analysis for the best SNP-SNP and gene-depression interaction models.

Locus No.	Best combination	Training	Testing	CV	Sign test (p)
Locus No.	Best combination	Accuracy	Accuracy	Consistency	Sign test (p)
SNP-SNP interactions
1	rs7577262	0.5472	0.5034	6/10	4 (0.8281)
2	rs17862920 rs2227283	0.5704	0.5313	8/10	8 (0.0547)
3	rs11568537 rs17862920 rs2227283	0.6034	0.5630	9/10	10 (0.0010) ^a
Gene-depression interactions
1	Depression	0.5988	0.5932	10/10	9 (0.0107) ^a
2	rs11110359 Depression	0.6123	0.5581	3/10	8 (0.0547)
3	rs11110359 rs55678639 Depression	0.6365	0.5917	5/10	9 (0.0107) ^a
4	rs10166942 rs3745521 rs8065080 Depression	0.6783	0.5963	9/10	10 (0.0010) ^a

Bold type indicates p < 0.05. Abbreviations: CV, Cross validation; GMDR, Generalized multifactor dimension reduction.

^{^a}

p adjusted factors: age, sex.