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. 2023 May 26;14:1194712. doi: 10.3389/fphar.2023.1194712

TABLE 3.

PB CD26+LSCs and BCR::ABL1 transcript at the time of TKI discontinuation, according to treatment. TFR: treatment-free remission.

Type of TKI before discontinuation Imatinib Nilotinib Dasatinib
Patients whole cohort (n = 109) 39 (35.8%) 49 (45.0%) 21 (19.2%)
CD26+LSCs at TKI discontinuation
POSITIVE (range) 19/39 (48.7%) (0,0048–0,1184 cells/μL) 30/49 (61.2%) (0,0001–0,1039 cells/μL) 12/21 (57.1%) (0,0063–0,0695 cells/μL)
NEGATIVE 20 (51.3%) 19 (38.8%) 9 (42.9%)
BCR::ABL1 transcript at TKI discontinuation
POSITIVE (range) 19/39 (48.7%) (0,001–0,0046 copies) 26/49 (53.1%) (0,00024–0,007 copies) 10/21 (47.6%) (0,001–0,029 copies)
NEGATIVE 20/39 (51.3%) 23/49 (46.9%) 11/21 (52.4%)