Table 5.

Clinical trials of the uterine microbiome, without the exclusion criteria of fibroid, leiomyoma, myoma (ClinicalTrials.gov website, February 2023).

Identifier	Sponsor	Condition	Intervention/treatment	Study Type	Estimated enrollment	Aim	Material	Criteria		Outcome Measures
								Inclusion	Exclusion
NCT05337072	Universitair Ziekenhuis Brussel	Endometritis; Chronic subfertility	Diagnostic Test: Microbiome study	Observational	1000 participants	To gain insight into the microorganisms that are present in the female reproductive tract based on various techniques	Endometrial biopsy and a vaginal swab	•Women planned for IVF/ICSI treatment •Women who undergo a diagnostic hysteroscopy in preparation for their treatment	•interventional hysteroscopy planned •previous history of chronic endometritis •use of antibiotics in the last 3 months	•Microbiome evaluated through metagenomics sequencing and high-throughput culturomics
NCT03405883	University Hospital, Ghent	Repeated implantation failure; Normal fertile	Vaginal swab and endometrial biopsy	Observational	40 participants	To characterize the uterine microbiome in women with repeated implantation failure as well as in normal fertile women	Obtained vaginal swab and endometrial biopsy in the midluteal phase of the cycle	•18-40 years old (max 39 years and 364 days at the day of signing the informed consent) •Negative serological tests for HIV, HBV, HCV, RPR for syphilis	•Hormonal contraception •Intra-uterine device use •Antibiotic treatment in the current cycle	Midluteal vaginal and endometrial microbiome profile Microbiome analysis using 16S ribosomal RNA sequencing