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. 2023 Jun 8;6(8):e202301957. doi: 10.26508/lsa.202301957

Figure S4. Impaired anxiety, sociability, and spatial learning and memory in adult offspring born to PE mothers.

Figure S4.

(A, B, C) Time spent in the closed arm of the elevated plus maze; (B) total travel distance in the open-field test in control and PE-exposed adult offspring mice (left panel: males, right panel: females); (C) social quotient, calculated as (time spent in the social chamber - time spent in the non-social chamber) /time spent in the middle chamber, in the three-chamber test (n = 20 offspring from 5 litters per gender per group). (D, E) Latency to the platform during training sessions and (E) time spent in each quadrant during the probe session in the Morris water maze (n = 16 offspring from 4 litters per gender per group). Data are presented as the mean ± s.e.m. NS, P ≥ 0.05; *, P < 0.05; **, P < 0.01; ***, P < 0.001, versus control. (A, B, C, D, E) Unpaired test was used for panels (A, B, C), and multiple t tests with the Holm–Sidak correction were used for panels (D, E).