. 2023 Jun 1;27(6):339–347. doi: 10.14744/AnatolJCardiol.2023.2825

Table 1.

Cardiac and ECG Measurements of Animals According to Study Groups

	Control^a	DAPA^b	DOX^c	DAPA + DOX^d	P _groups	P _measures
First weight measurement, g	272.00 ± 36.72	299.60 ± 16.95	287.90 ± 17.51	287.10 ± 17.40	<.001^* a–c a–d	<.001^*
Second weight measurement, g	301.40 ± 42.25	301.50 ± 15.23	273.40 ± 18.31	242.10 ± 21.08
Third weight measurement, g	338.20 ± 43.37	325.00 ± 21.53	280.00 ± 21.00	265.33 ± 23.21
Fourth weight measurement, g	338.10 ± 41.49	325.00 ± 22.45	275.50 ± 24.22	275.88 ± 21.24
Ejection fraction, baseline, %	79.30 ± 2.40	79.10 ± 2.23	78.50 ± 2.46	78.00 ± 3.01	<.001^* a–c	<.001^*
Ejection fraction, week 6, %	78.80 ± 2.57	80.90 ± 3.10	66.00 ± 9.98	74.00 ± 4.03	<.001^* a–c	<.001^*
Fractional shortening baseline, %	47.20 ± 3.88	47.20 ± 4.51	49.30 ± 5.20	46.70 ± 4.49	.764	<.001^*
Fractional shortening week 6, %	48.10 ± 4.40	47.40 ± 4.76	43.20 ± 4.73	44.33 ± 3.80	.764	<.001^*
End-diastolic volume baseline, μL	275.70 ± 12.18	271.90 ± 15.83	269.20 ± 12.73	278.80 ± 22.92	.141	<.001^*
End-diastolic volume week 6, μL	277.50 ± 11.22^a	269.65 ± 15.53^b	307.70 ± 35.32^a.b	284.11 ± 16.91	.141	<.001^*
End-systolic volume baseline, μL	57.50 ± 10.42	65.90 ± 7.63	55.00 ± 7.36^a	66.30 ± 11.64^a	.205	<.001^*
End-systolic volume week 6, μL	59.10 ± 10.25	65.20 ± 8.09	68.70 ± 11.64	68.77 ± 10.38	.205	<.001^*
Heart rate baseline, bpm	331.30 ± 24.09	352.60 ± 28.96	358.10 ± 19.30	345.90 ± 28.51	.026^* a–c	.014
Heart rate week 6, bpm	331.70 ± 24.77^a	354.40 ± 25.25	378.90 ± 42.82^a	348.33 ± 25.42	.026^* a–c	.014
QTc baseline, ms	171.40 ± 19.96	169.80 ± 17.11	170.90 ± 18.71	171.30 ± 17.99	.525	<.001^*
QTc week 6, ms	171.80 ± 19.67	169.20 ± 14.92	192.30 ± 28.91	174.77 ± 16.72	.525	<.001^*
QRS baseline, ms	14.70 ± 2.21	14.90 ± 2.23	14.80 ± 2.74	15.00 ± 2.10	.001^* a–c	<.001^*
QRS week 6, ms	14.90 ± 2.23^a	14.70 ± 2.11^b	23.10 ± 4.38^a.b.c	15.77 ± 1.92^c	.001^* a–c	<.001^*

Data are given as mean ± SD.

^*Significant at the .05 level according to two-way repeated measure ANOVA.

^a,b,c,dThe letters denote the significant pairwise study groups according to Dunnet t (2-sided) post-hoc test.

bpm, beat per minute; DAPA, dapagliflozin; DOX, doxorubicin; QTc, corrected QT interval.