Table 2.
Hemodynamic results of head-up tilt testing of healthy controls (HC) and ME/CFS patients.
| HC (n = 52) | ME/CFS (n = 362) | Unpaired t-test | |
|---|---|---|---|
| HR supine (bpm) | 64 (10) | 72 (11) | < 0.0001 |
| HR end-tilt (bpm) | 78 (15) | 87 (11) | < 0.0001 |
| SBP supine (mmHg) | 134 (15) | 138 (18) | 0.17 |
| SBP end-tilt (mmHg) | 127 (14) | 135 (19) | 0.008 |
| DBP supine (mmHg) | 79 (7) | 80 (10) | 0.49 |
| DBP end-tilt (mmHg) | 81 (8) | 86 (11) | 0.002 |
| SVI supine (ml/m2) | 37 (5) | 37 (6) | 0.31 |
| SVI end-tilt (ml/m2) | 27 (4) | 22 (4) | < 0.0001 |
| CI supine (L/min/m2) | 2.30 (0.35) | 2.58 (0.43) | < 0.0001 |
| CI end-tilt (L/min/m2) | 2.04 (0.28) | 1.86 (0.34) | 0.0004 |
| CBF supine (ml/min) | 622 (82) | 612 (100) | 0.50 |
| CBF end-tilt (ml/min) | 584 (80) | 451 (89) | < 0.0001 |
CBF: cerebral blood flow; CI: cardiac index; DBP: diastolic blood pressure; end-tilt: upright measurements just before tilting the subject back to supine; HC: healthy controls; HR: heart rate; ME/CFS: myalgic encephalomyelitis/chronic fatigue syndrome; SBP: systolic blood pressure; SVI: stroke volume index. A p-value of < 0.01 is considered significant.