Table 1.
Cohort characteristics and association according to PET status
| Total (n=91) | Amyloid |
P | |||
|---|---|---|---|---|---|
| Positive (n=14) | Negative (n=77) | ||||
| Acute phase | |||||
| Age (yr) | 63.3±10.7 | 72.6±6.0 | 61.6±10.5 | <0.001 | |
| Male sex | 62 (68.1) | 10 (71.4) | 52 (67.5) | >0.99 | |
| Education (yr) | 10.5±2.8 | 9.6±1.7 | 10.6±2.9 | 0.20 | |
| Prestroke IQCODE score | 48.9±2.5 | 52.3±7.8 | 51.2±8.0 | 0.60 | |
| Prestroke modified Rankin Scale score | 0 [0–0] | 0 [0–0] | 0 [0–1] | 0.13 | |
| Prestroke 4IADL | 0.3±1.1 | 0.86±2.4 | 0.16±0.5 | 0.40 | |
| NIHSS on admission | 5.6±5.8 | 4.7±3.1 | 5.8±6.2 | 0.30 | |
| Acute complication | 26 (37.7) | 3 (30.0) | 23 (39.0) | 0.70 | |
| Delirium | 2 (2.9) | 0 (0.0) | 2 (3.4) | >0.99 | |
| Cause of stroke | |||||
| Infarct subgroup (n=81) | 81 (89.0) | 12 (85.7) | 69 (89.6) | 0.60 | |
| Atherosclerosis | 4 (4.9) | 0 (0.0) | 4 (5.8) | >0.99 | |
| Small vessel disease | 14 (17.3) | 4 (33.3) | 10 (14.5) | 0.20 | |
| Cardioembolic stroke | 20 (24.7) | 4 (33.3) | 16 (23.2) | 0.50 | |
| Other | 8 (9.8) | 1 (8.3) | 7 (10.1) | 0.80 | |
| Hemorrhage subgroup (n=10) | 10 (11.0) | 2 (14.3) | 8 (10.4) | ||
| Hypertensive | 5 (50.0) | 0 (0.0) | 5 (62.5) | 0.40 | |
| Amyloid angiopathy | 3 (30.0) | 2 (100) | 1 (12.5) | 0.06 | |
| Other | 2 (20.0) | 0 (0.0) | 2 (25.0) | >0.99 | |
| Inclusion | |||||
| Time poststroke (days) | 808±589 | 660±515 | 835±601 | 0.30 | |
| Recurrent stroke | 1 (1.1) | 0 | 1 (1.3) | >0.99 | |
| NIHSS | 1.49±2.02 | 0.86±2.4 | 0.16±0.5 | 0.80 | |
| Depressive symptoms | 14.5±11.3 | 15.7±11.1 | 14.3±11.3 | 0.70 | |
| MMSEa score | 25.9±3.6 | 23.1±4.8 | 26.4±3.1 | 0.02 | |
| MoCA score | 22.3±4.4 | 16.7±4.9 | 22.7±4.2 | 0.03 | |
| 4IADL | 1.76±2.31 | 2.0±3.16 | 1.71±2.14 | 0.70 | |
| Depressive symptoms | 14.5±11.3 | 15.7±11.1 | 14.3±11.3 | 0.70 | |
| Behavioral dysexecutive score | 1.76±2.31 | 2.0±3.16 | 1.71±2.14 | 0.70 | |
| 4IADL | 1.76±2.31 | 2.0±3.16 | 1.71±2.14 | 0.70 | |
| modified Rankin Scale score | 2 [1–3] | 2 [1–3] | 2 [1–3] | 0.90 | |
Data are expressed as n (%), mean±standard deviation, or median [interquartile range].
PET, positron emission tomography; IQCODE, Informant Questionnaire on Cognitive Decline in the Elderly; 4IADL, score on 4 Instrumental Activities of Daily Living; NIHSS, National Institutes of Health Stroke Scale; MMSEa, education-adjusted score on the Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment.