Table 2.
Comparison of blood lipid levels between groups before and after treatment
Variable | Control group (n=55) | PCSK9 inhibitor group (n=55) | t | P | |
---|---|---|---|---|---|
TG (mmol/L) | Before treatment | 1.86±0.87 | 1.84±0.96 | 0.115 | 0.909 |
After treatment | 1.52±0.73 | 1.21±0.81 | 2.108 | 0.037 | |
t | 2.220 | 3.719 | |||
P | 0.029 | <0.001 | |||
TC (mmol/L) | Before treatment | 5.78±1.15 | 5.81±1.35 | -0.126 | 0.900 |
After treatment | 4.61±1.04 | 3.67±1.03 | 4.7627 | <0.001 | |
t | 5.596 | 9.346 | |||
P | <0.001 | <0.001 | |||
HDL-C (mmol/L) | Before treatment | 1.04±0.27 | 1.05±0.29 | -0.187 | 0.852 |
After treatment | 1.15±0.24 | 1.21±0.25 | -1.284 | 0.202 | |
t | -2.258 | -3.099 | |||
P | 0.026 | 0.003 | |||
LDL-C (mmol/L) | Before treatment | 3.94±0.76 | 3.87±1.17 | 0.372 | 0.711 |
After treatment | 2.51±0.86 | 1.82±0.97 | 3.947 | <0.001 | |
t | 9.240 | 10.003 | |||
P | <0.001 | <0.001 | |||
Lp(a) (mg/L) | Before treatment | 321.23±102.43 | 320.78±100.96 | 0.023 | 0.982 |
After treatment | 318.87±97.23 | 241.93±94.45 | 4.210 | <0.001 | |
t | 0.124 | 4.230 | |||
P | 0.902 | <0.001 |
Note: All data are presented mean ± SD. Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Lp(a), lipoprotein(a); PCSK9, proprotein convertase subtilisin/kexin 9; TC, total cholesterol; TG, triglycerides.