. 2023 Apr 21;130(6):729–746. doi: 10.1016/j.bja.2023.03.008

Table 4.

Three groups of fMRI experiments and two groups of voxel based morphology significant meta-analysis results using GingerALE. ALE, Activation likelihood estimation; BA, Brodmann area; CP, chronic pain; ELA, early life adversity; Hem, Hemispheres; MDD, major depressive disorder; MNI, Montreal Neurological Institute coordinates. ∗ Broadman Area not applicable.

Cluster	Hem	Lobes	Brain regions	BA	MNI			ALE	P	Z
Cluster	Hem	Lobes	Brain regions	BA	x	y	z	ALE	P	Z
*fMRI meta-analysis results*
MDD with adverse childhood experiences (n=95) compared with HC (n=69)⁵⁹^,⁷⁴^,⁷⁶								164 participants
1	Left	Parietal	Superior parietal lobule	7	–30	–42	48	0.0012	0.0180	2.09
1	Left	Parietal	Inferior parietal lobule	40	–33	–49	49	0.0086	0.0003	3.41
2	Right	Limbic	Parahippocampal gyrus	30	21	–48	4	0.0009	0.0210	2.03
2	Right	Limbic	Parahippocampal gyrus	30	12	–49	5	0.0090	0.0002	3.62
3	Left	Frontal	Middle frontal gyrus	9	–42	14	22	0.0095	2.3E–05	4.08
	Left	Frontal	Inferior frontal gyrus	9	–54	23	22	0.0092	6.1E–05	3.84
	Left	Frontal	Middle frontal gyrus	9	–45	29	31	0.0086	0.0003	3.41
4	Right	Frontal	Middle frontal gyrus	9	35	35	31	0.0051	0.0031	2.73
5	Left	Temporal	Middle temporal gyrus	37	–60	–52	–11	0.0092	6.1E–05	3.84
5	Left	Temporal	Inferior temporal gyrus	37	–57	–46	–17	0.0089	0.0002	3.52
6	Right	Sublobar	Putamen/globus pallidus	∗	20	–4	10	0.0065	0.0014	2.99
MDD with adverse childhood experiences (n=116) compared with MDD without adverse childhood experiences (n=154)⁵⁹^,⁶⁶^,⁷¹^,⁷⁴								270 participants
1	Right	Occipital	Middle occipital gyrus	18	29	–90	24	0.0180	1.1E–08	5.6
	Right	Occipital	Superior occipital gyrus	19	24	–90	38	0.0170	8.1E–08	5.24
	Right	Occipital	Cuneus	18	22	–81	28	0.0000	0.0830	1.38
	Right	Parietal	Precuneus	7	23	–61	45	0.0005	0.0440	1.71
2	Left	Parietal	Superior parietal lobule	40	–36	–54	51	0.0022	0.0160	2.15
2	Left	Parietal	Inferior parietal lobule	40	–33	–40	49	0.0000	0.0800	1.4
MDD or CP or HC: with adverse childhood experiences (n=139) > without adverse childhood experiences (n=217)⁶⁶^,⁷¹^,⁷⁴^,⁸⁸^,⁸⁹								356 participants
1	Left	Limbic	Posterior cingulate gyrus	31	–12	–34	42	0.0110	1.4E–05	4.18
		Parietal	Inferior parietal lobule	40	–36	–54	51	0.0022	0.0200	2.05
	Left	Parietal	Precuneus	7	–20	–46	48	0.0070	0.0018	2.92
	Left	Parietal	Inferior parietal lobule	40	–45	–34	49	0.0069	0.0018	2.91
*Structural (VBM) meta-analysis results*
MDD with adverse childhood experiences (n=154) compared with MDD without adverse childhood experiences (n=123)⁵²^,⁵³^,⁶⁵^,⁷⁰^,⁸⁵								277 participants
1	Left	Anterior	Cerebellum	∗	–2	–58	–6	0.0093	2.5E–05	4.06
	Left	Occipital	Lingual gyrus	18	–8	–72	6	0.0090	3.2E–05	3.99
	Left	Anterior	Cerebellum	∗	–6	–50	–20	0.0089	0.0001	3.81
	Right	Anterior	Cerebellum	∗	8	–34	–14	0.0078	0.0004	3.37
2	Right	Temporal	Hippocampus	∗	32	–37	5	0.0075	0.0004	3.36
3	Right	Sub-lobar	Superior insula	∗	27	–13	20	0.0078	0.0004	3.37
4	Left	Sub-lobar	Putamen	∗	–25	–17	18	0.0078	0.0004	3.37
5	Left	Temporal	Superior temporal gyrus	41	–51	–33	14	0.0084	0.0001	3.71
6	Right	Temporal	Inferior temporal gyrus	20	46	–32	–21	0.0086	8.1E–05	3.77
7	Left	Frontal	Superior frontal gyrus	8	–17	32	37	0.0090	6.5E–05	3.83
8	Right	Frontal	Superior frontal gyrus	6	26	11	51	0.0090	6.5E–05	3.83
MDD and HC with adverse childhood experiences (n=315) >MDD and HC without adverse childhood experiences (n=313)⁵²^,⁵³^,⁶⁴^,⁶⁵^,⁷⁰^,⁸⁰^,⁸⁵								628 participants
1	Left	Occipital	Lingual gyrus	18	–8	–72	6	0.0180	1.7E–08	5.52
	Left	Anterior	Cerebellum	∗	–2	–58	–6	0.0093	0.0001	3.74
	Left	Anterior	Cerebellum	∗	–6	–50	–20	0.0089	0.0002	3.58