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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: Neuroimage. 2020 Jun 20;220:117067. doi: 10.1016/j.neuroimage.2020.117067

Table 6.

Genetic and environmental correlation of personality brain associations in the full HCP sample.

Cortical thickness ROI Environmental correlation Genetic correlation Genetic contribution to phenotypic correlation
Agreeableness LH Cont_PFCl_4 ρe −0.12, p < 0.05* ρg −0.09, p = ns 22%
LH Default_PFC_9 ρe −0.05, p = ns ρg −0.21, p < 0.1 72%
LH Default_PFC_11 ρe 0.01, p = ns ρg −0.36, p < 0.005** 100%
LH Default_PFC_13 ρe −0.03, p = ns ρg −0.26, p < 0.05* 84%
RH Default_PFCm_5 ρe 0.03, p = ns ρg −0.33, p < 0.01** 100%
Neuroticism LH Vis_14 ρe −0.07, p = ns ρg −0.20, p < 0.1 64%
LH Default_PFC_9 ρe 0.07, p = ns ρg 0.17, p = ns 63%
RH Cont_PFCl_6 ρe 0.03, p = ns ρg 0.27, p < 0.05* 82%
RH Default_PFCm_5 ρe 0.03, p = ns ρg 0.23, p < 0.05* 83%
Openness LH Cont_PFCl_4 ρe −0.13, p < 0.05* ρg −0.14, p = ns 43%
RH Limbic_TempPole_1 ρe 0.01, p = ns ρg 0.34, p < 0.01** 95%
Surface area Neuroticism LH SomMot_3 ρe 0.03, p = ns ρg −0.29, p < 0.02* 100%
LH Default_PFC_3 ρe −0.05, p = ns ρg −0.17, p = ns 71%
LH Default_PFC_9 ρe 0.13, p < 0.1 ρg −0.45, p = 0.0002** 100%
LH Default_PFC_13 ρe −0.04, p = ns ρg −0.21, p = ns 75%
RH Default_Temp_1 ρe −0.16, p < 0.02 ρg 0.00, p = ns 1%
RH Default_PFCm_4 ρe 0.01, p = ns ρg −0.25, p < 0.02* 100%
RH Default_PFCm_5 ρe −0.04, p = ns ρg −0.30, p < 0.02* 81%

Genetic and environmental correlations are computed in the HCP sample, and exact p-values are reported.

**

denotes a significant genetic correlation at FDRq<0.05, corrected for the number of ROIs associated with the respective personality trait within the structural marker.

*

indicated an association of p < 0.05. The genetic contribution of phenotypic correlation was computed using the respective heritability of the personality trait and the local parcel as well as their genetic and phenotypic correlation.