Skip to main content
. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: Neuropharmacology. 2021 Nov 3;202:108870. doi: 10.1016/j.neuropharm.2021.108870

Table 2.

Pre-clinical immunotherapy studies.

Model Compound Route of
Administration		 Mechanism Effect on aSyn Effect on
Inflammation		 Effect on Behavior References
MBP- aSyn transgenic mice AFFITOPE® (AFF 1) SC Targets C-terminus of aSyn Reduced aSyn aggregates AFF1 activated microglia; ↑ anti-inflammatory IL-1Ra, IL-3, and IFNγ Motor improvements: ↓ errors on round beam test Mandler et al. (2015)
Transgenic mice mThy1- aSyn, line 61 PRX002 IP Targets C-terminus of aSyn Reduced intracellular aSyn ↓ astroglia and microglia; preserved TH in striatum Motor, learning, and memory improvements: ↓ errors on round beam; ↓ path and latency to platform in water maze Games et al. (2014)
Transgenic aSyn A53T (M83) mice & Transgenic BAC aSyn A53T BIIB045 IP Targets N-terminus on aSyn aggregates Reduced aSyn pathology Not measured Motor improvements: ↑ latency in time to fall in wire hang test Weihofen et al. (2019)