Table 9.

Comparison of various studies using low-level laser therapy in androgenetic alopecia

Study	Sample size	Grade of AGA	Intervention	Result (mean increase in hair density in LLLT and control group)
Leavitt et al., 2009[13]	110 male patients	Norwood–Hamilton 2-5	HairMax LaserComb, 655± (5%) nm for 26 weeks	LLLT group: 19.8 hairs/cm2 Control (sham) group: −7.6 hairs/cm2
Kim et al., 2013[14]	40 male and female patients	Norwood–Hamilton 3-6 Ludwig 1 and 2	Helmet type LLLT device, 650 nm laser with 630 and 660 nm LEDs for 24 weeks	LLLT group: 17.2 hairs/cm2 Control (sham) group: −2.1 hairs/cm2
Lanzafame et al., 2013[15]	44 male patients	Norwood–Hamilton 2-5	Helmet (TOPHAT655) 655±5 nm for 16 weeks	LLLT group: 67.2 hairs/cm2 Control (sham) group: 32.3 hairs/cm2
Faghihi et al., 2018[16]	50 males and females	Norwood–Hamilton 3-6 for male, Ludwig 2-3 for female	LDU 8024PN/8024BN, 785-nm wavelength for 24 weeks	No significant differences at 3 and 6 months, however, significant difference was found at 9 and 12 months after the intervention LLLT + minoxidil group: 78.3% Minoxidil group: 51.3%
Suchonwanit et al., 2019[17]	40 males and females	Norwood–Hamilton 3-5 for male, Ludwig 1-3 for female	RAMACAP a combat helmet-shaped device 660±10 nm wavelength for 24 weeks	LLLT group: 10.21±3.25 hairs/cm2 Control (sham) group: 3.95±1.32 hairs/cm2
Present study	54 male patients	Norwood–Hamilton 2-4	Hairmax LaserComb 655 nm for 16 weeks	LLLT+minoxidil group: 34.5 hairs/cm2 Minoxidil group: 24.21 hairs/cm2

ADR – Adverse drug reactions; LLLT – Low-level laser therapy; LEDs – Light emitting diodes