Table 3:
Logistic regression (outcome: SPPB), adjusted for demographic, lesion and cognition measures.
| MODEL #2 – Adjusted for demographics, lesion and cognitive covariates | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MS | HC | |||||||||||||
| Brain Measures | Demographic/Clinical Measures | Brain Measures | Demographic/Clinical Measures | |||||||||||
| Circuit | FA | T2LL | Age | Sex | GHS | Education | RBANS | FA | T2LL | Age | Sex | GHS | Education | RBANS |
|
|
||||||||||||||
| dStr - aDLPFC (R) | 1.16 (0.53) 0.73 – 1.85 |
3.64 (0.014)*
1.30 – 10.17 |
1.46 (0.13) 0.89 – 2.38 |
1.48 (0.10) 0.93 – 2.36 |
1.13 (0.59) 0.72 – 1.79 |
0.93 (0.75) 0.62 – 1.42 |
1.14 (0.60) 0.70 – 1.88 |
0.60 (0.053) 0.36 – 1.01 |
0.76 (0.23) 0.48 – 1.20 |
0.82 (0.42) 0.52 – 1.31 |
1.18 (0.47) 0.75 – 1.83 |
1.59 (0.065) 0.97 – 2.60 |
1.33 (0.23) 0.84 – 2.10 |
0.45 (0.003)
**
0.26 – 0.76 |
|
| ||||||||||||||
| dStr - aDLPFC (L) | 1.18 (0.48) 0.74 – 1.88 |
3.71 (0.012)* 1.33 – 10.36 |
1.47 (0.12) 0.90 – 2.40 |
1.49 (0.095) 0.93 – 2.38 |
1.15 (0.53) 0.74 – 1.81 |
0.94 (0.76) 0.62 – 1.42 |
1.15 (0.58) 0.70 – 1.88 |
0.33 (0.003)
*
*
0.15 – 0.69 |
0.56 (0.052) 0.31 – 1.01 |
0.86 (0.55) 0.51 – 1.43 |
1.22 (0.43) 0.74 – 2.02 |
1.67 (0.064) 0.97 – 2.89 |
1.76 (0.068) 0.96 – 3.23 |
0.39 (0.002)
**
0.21 – 0.72 |
|
| ||||||||||||||
| dStr - pDLPFC (R) | 1.37 (0.20) 0.84 – 2.23 |
3.76 (0.012)* 1.33 – 10.58 |
1.46 (0.14) 0.89 – 2.40 |
1.60 (0.064) 0.97 – 2.62 |
1.13 (0.60) 0.72 – 1.78 |
0.92 (0.69) 0.61 – 1.39 |
1.16 (0.56) 0.71 – 1.89 |
0.57 (0.066) 0.32 – 1.04 |
0.76 (0.25) 0.48 – 1.21 |
0.82 (0.41) 0.52 – 1.31 |
1.11 (0.64) 0.71 – 1.74 |
1.57 (0.061) 0.98 – 2.50 |
1.28 (0.30) 0.80 – 2.06 |
0.49 (0.006)
**
0.29 – 0.81 |
|
| ||||||||||||||
| dStr - pDLPFC (L) | 1.12 (0.65) 0.69 – 1.81 |
3.49 (0.015)* 1.27 – 9.53 |
1.45 (0.13) 0.90 – 2.36 |
1.53 (0.096) 0.93 – 2.52 |
1.14 (0.56) 0.73 – 1.80 |
0.91 (0.64) 0.60 – 1.37 |
1.17 (0.53) 0.72 – 1.90 |
0.58 (0.074) 0.32 – 1.06 |
0.75 (0.23) 0.47 – 1.20 |
0.82 (0.40) 0.52 – 1.30 |
1.19 (0.45) 0.76 – 1.85 |
1.50 (0.092) 0.94 – 2.42 |
1.42 (0.16) 0.87 – 2.34 |
0.48 (0.006)**
0.28 – 0.81 |
|
| ||||||||||||||
| vStr - VMPFC (R) | 0.91 (0.76) 0.51 – 1.64 |
3.48 (0.017)* 1.25 – 9.67 |
1.44 (0.13) 0.89 – 2.33 |
1.46 (0.11) 0.92 – 2.34 |
1.15 (0.54) 0.73 – 1.80 |
0.91 (0.64) 0.59 – 1.38 |
1.19 (0.50) 0.72 – 1.96 |
0.72 (0.15) 0.45 – 1.13 |
0.86 (0.48) 0.56 – 1.31 |
0.83 (0.39) 0.53 – 1.28 |
1.18 (0.47) 0.76 – 1.82 |
1.71 (0.030)
*
1.05 – 2.77 |
1.29 (0.27) 0.82 – 2.03 |
0.45 (0.003)
**
0.26 – 0.76 |
|
| ||||||||||||||
| vStr - VMPFC (L) | 1.08 (0.76) 0.66 – 1.78 |
3.64 (0.016)* 1.28 – 10.37 |
1.46 (0.13) 0.89 – 2.37 |
1.48 (0.10) 0.92 – 2.37 |
1.16 (0.52) 0.74 – 1.82 |
0.93 (0.73) 0.61 – 1.41 |
1.15 (0.57) 0.70 – 1.90 |
0.33 (0.004)
**
0.16 – 0.70 |
0.67 (0.36) 0.29 – 1.57 |
0.74 (0.21) 0.46 – 1.19 |
1.34 (0.28) 0.78 – 2.30 |
2.34 (0.012)
*
1.21 – 4.55 |
1.53 (0.10) 0.92 – 2.56 |
0.33 (0.001)
**
0.18 – 0.62 |
Values represent Odds ratio (p-value), 95% confidence interval. Significant results are shown in bold
*:
p < 0.05
**:
p < 0.01.
Abbreviations: dStr: dorsal striatum; a/pDLPFC: anterior/posterior dorsolateral prefrontal cortex; FA: fractional anisotropy; GHS: Global health score; RBANS: Repeatable battery for the assessment of neuropsychological status; T2LL: T2 lesion load; vStr: ventral striatum; VMPFC: ventromedial prefrontal cortex.