Table 4:
Logistic regression model (outcome: SPPB) in MS patients only, adjusted for demographic and lesion measures, cognition and patient reported ambulatory function (PDDS) scores.
| MODEL #3 - Add PDDS covariate | MS only | |||||||
|---|---|---|---|---|---|---|---|---|
| Brain Measures | Demographic/Clinical Measures | |||||||
| Circuit | FA | T2LL | Age | Sex | GHS | Education | RBANS | PDDS |
|
|
||||||||
| dStr - aDLPFC (R) | 0.76 (0.46) 0.37 – 1.56 |
4.76 (0.011)* 1.43 – 15.83 |
2.17 (0.032)* 1.07 – 4.42 |
1.45 (0.15) 0.87 – 2.43 |
1.07 (0.78) 0.66 – 1.75 |
0.89 (0.62) 0.55 – 1.43 |
1.46 (0.21) 0.81 – 2.62 |
2.51 (0.014)* 1.20 – 5.23 |
|
| ||||||||
| dStr - aDLPFC (L) | 0.63 (0.19) 0.31 – 1.26 |
4.93 (0.011)* 1.44 – 16.92 |
2.42 (0.031)* 1.08 – 5.38 |
1.39 (0.22) 0.82 – 2.36 |
1.01 (0.96) 0.62 – 1.65 |
0.89 (0.63) 0.55 – 1.44 |
1.51 (0.17) 0.84 – 2.73 |
3.11 (0.010)* 1.31 – 7.40 |
|
| ||||||||
| dStr - pDLPFC (R) | 1.00 (0.99) 0.55 – 1.81 |
4.52 (0.010)* 1.44 – 14.13 |
2.01 (0.036)* 1.05 – 3.86 |
1.47 (0.15) 0.87 – 2.49 |
1.04 (0.87) 0.64 – 1.69 |
0.91 (0.68) 0.57 – 1.44 |
1.37 (0.28) 0.78 – 2.39 |
2.17 (0.017)* 1.15 – 4.10 |
|
| ||||||||
| dStr - pDLPFC (L) | 0.57 (0.13) 0.28 – 1.17 |
6.62 (0.008)** 1.62 – 27.01 |
2.43 (0.023)* 1.13 – 5.22 |
1.20 (0.51) 0.69 – 2.10 |
1.05 (0.85) 0.64 – 1.71 |
0.99 (0.98) 0.60 – 1.64 |
1.46 (0.21) 0.81 – 2.62 |
3.20 (0.005)** 1.43 – 7.15 |
|
| ||||||||
| vStr - VMPFC (R) | 0.37 (0.077) 0.12 – 1.11 |
5.28 (0.012)* 1.44 – 19.33 |
2.91 (0.014)* 1.24 – 6.83 |
1.57 (0.12) 0.89 – 2.77 |
0.88 (0.63) 0.52 – 1.48 |
0.83 (0.47) 0.50 – 1.38 |
1.83 (0.088) 0.91 – 3.65 |
3.56 (0.008)** 1.39 – 9.12 |
|
| ||||||||
| vStr - VMPFC (L) | 0.81 (0.59) 0.39 – 1.72 |
4.35 (0.012)* 1.38 – 13.69 |
2.04 (0.034)* 1.06 – 3.95 |
1.45 (0.16) 0.87 – 2.42 |
1.03 (0.90) 0.64 – 1.66 |
0.88 (0.61) 0.55 – 1.42 |
1.43 (0.23) 0.80 – 2.55 |
2.29 (0.011)* 1.21 – 4.33 |
Values represent Odds ratio (p-value), 95% confidence interval. Significant results are shown in bold
*
: p < 0.05
**
: p < 0.01.
Abbreviations: dStr: dorsal striatum; a/pDLPFC: anterior/posterior dorsolateral prefrontal cortex; FA: fractional anisotropy; GHS: Global health score; PDDS: Patient determined disease steps; RBANS: Repeatable battery for the assessment of neuropsychological status; T2LL: T2 lesion load; vStr: ventral striatum; VMPFC: ventromedial prefrontal cortex.