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. 2023 Jun 9;13:9403. doi: 10.1038/s41598-023-36428-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Stability of a modified and a non-modified aptamer was demonstrated by incubating A549 cells with aptamer infused growth media. The oligonucleotide concentration was determined by real-time PCR at the indicated time points. The degradation of aptamers was remarkably different, the modified aptamer seems to possess an approx. 8 times longer half-life in comparison to its non-modified variant. Error bars represent the standard deviation of three individual experiments (N = 3).