Table 4.

Recommendations on routine laboratory tests and monitoring of adverse events for OPAT in Brazil according to the Brazilian guidelines.

Antimicrobial	Laboratory tests to be performed and periodicity					Considerations
	Complete blood cell analysis	Renal evaluation (urea and creatinine)	Hepatic evaluation (AST, ALT, alkaline phosphatase, and gamma GT)	Potassium	CPK
Amikacin	14 days	7 days	14 days	7 days	–	Ototoxicity may occur: monitor hearing and vestibular functions
Gentamicin	14 days	7 days	14 days	7 days	–	Ototoxicity may occur: monitor hearing and vestibular functions
Cefepime	14 days	14 days	14 days	–	–
Ceftaroline	14 days	14 days	14 days	–	–
Ceftazidime	14 days	14 days	14 days	–	–
Ceftriaxone	14 days	14 days	7 days	–	–
Ertapenem	14 days	14 days	14 days	–	–	A decrease in the convulsive threshold may occur
Meropenem	14 days	14 days	14 days	–	–	A decrease in the convulsive threshold may occur
Vancomycin	7 days	7 days	7 days	7 days	–	Serum level control (vancomycin) can be performed every 7 days
Teicoplanin	14 days	14 days	14 days	–	–
Daptomycin	14 days	14 days	14 days	–	7 days
Linezolid	7 days	14 days	14 days	–	–	Optical neuropathy may occur: monitor visual acuity
Tigecycline	14 days	14 days	7 days	–	–	Nausea may occur even in the absence of hepatic enzyme alterations: consider concomitant administration of antiemetics
Anidulafungin	14 days	14 days	14 days	–	–
Caspofungin	14 days	14 days	14 days	–	–
Micafungin	14 days	14 days	14 days	–	–
Voriconazole	14 days	14 days	14 days	–	–
Amphotericin B (lipid complex)	7 days	3 days	7 days	3 days	–	Weekly test of magnesium may be necessary
Amphotericin B (liposomal)	7 days	3 days	7 days	3 days	–	Weekly test of magnesium may be necessary

ALT, alanine transaminase; AST, aspartate transaminase; CPK, creatine phosphokinase; GT, glutamyl transferase; OPAT, outpatient parenteral antimicrobial therapy.