Scheme 2. Synthesis of the Target Compounds 1–4.
Reagents and conditions. (a) 8, EDCI, HOBT, DIPEA, DMF, rt, 12 h, 32% yield for 1, 25% yield for 3; (b) 14, EDCI, HOBT, DIPEA, DMF, rt, 12 h, 48% yield for 2, 44% yield for 4.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.