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. 2023 May 22;10:1181965. doi: 10.3389/fmolb.2023.1181965

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Copyright © 2023 Cappuccio, Khalil, Osenberg, Li and Maletic-Savatic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sphingolipid CerPE 36:1; O2 is selectively abundant in rosettes, while PE 38:3 is selectively absent from rosettes. Positive (A) and negative (B) ion mode shows overlaid distribution of CerPE 36:1; O2 and PE 38:3 in two 60-day-old brain organoids. Confocal micrographs of sections adjacent to the sections used for MSI show expression of DAPI (nuclear stain), PAX6 (marker of neuroprogenitors localized in rosettes) and doublecortin (DCX, marker of immature neurons). Inset in (B) is a high magnification of a rosette, showing expression of PA×6 and not DCX.