Fig. 4.

a Pairwise comparison of the 46 datasets pACTIVITY distributions computed by Kolmogorov–Smirnov statistical test. Analogously, b. depicts the average Tanimoto similarity coefficient among the compounds of the given datasets pair. The color scale has been normalized between 0 and 1: higher values (red) indicate that the given datasets pair show significantly different distributions a and higher chemical similarity b, as opposed to values closer to 0 (blue). Marked rows and columns with codes T1-6 highlight some targets referenced in the text, in order: ADRB1, ESR1, HTR1A, KNCH2, MAOA, PTGS1