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IC50 values of EGFR and HER2 kinase activities of the most potent compounds
| Compound | IC50 [nM]a | |
|---|---|---|
| EGFR kinase | HER2 kinase | |
| 18b | 7.04 | 16.3 |
| 18c | 4.98 | 9.85 |
| 21a | 5.8 | 14.2 |
| Lapatinib | 6.1 | 17.2 |
aValues are expressed as an average of three independent replicates. IC50 values were calculated using a sigmoidal non-linear regression curve fit of percentage inhibition against five concentrations of each compound
