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Transactivation potential of co-transfected wild-type and mutant HNF4α on the human HNF1 promoter. Co-transfection of wild-type HNF4α and either R127W (A) or R154X (B) was done with the amount of expression vector given. In each experiment the amount of reporter gene construct and total DNA transfected was constant. Fold induction refers to the activity with no HNF4α derivative and the error bars indicate standard deviation of six determinations.
