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. 2023 Jun 9;26(7):107085. doi: 10.1016/j.isci.2023.107085

Figure 1.

Figure 1

Authentic virus neutralization of SARS-CoV-2 variants by W25, EUA, and other mAbs

(A) Neutralization curves comparing the sensitivity of SARS-CoV-2 strains Wu (gray line) and Omicron BA.1 (red line) and Omicron BA.2 (blue line) to antibody as indicated including W25-Fc, C05, CB6, REGN10933, CT-P59, LY-CoV555, S309, REGN10987, and DH1047. The data were analyzed and plotted using nonlinear regression (curve fit, three parameters).

(B and C) Comparison of IC50 values across mAbs tested between Wu and Omicron. IC50 was calculated from the neutralization curve by Graphpad Prism 8 software. Color represents different mAbs as indicated. Data are generated from two independent experiments, each performed in technical triplicate. Data are represented as mean ± SEM.