Table 1.
Summary statistics of pharmacokinetic parameters for the fasted vs. fed group.
| Cat group | Cmax1 (ng/mL) Mean ±SD | Tmax2 (Hours) Mean ±SD† | Terminal half-life harmonic Mean ±Psuedo-SD | AUC3 (h*ng/mL) Mean ±SD† | MRT4 (Hours) Mean ±SD | VzF5 (L/Kg) Mean ±SD | CLssF6 (L/h/kg) Mean ±SD |
|---|---|---|---|---|---|---|---|
| Fasted | 269 ± 334* | 2.6 ± 1.6 | 4.1 ± 4.4 | 921 ± 1,003** | 12.1 ± 7.5 | 668.3 ± 1,130 | 16 ± 10.1 |
| Fed | 465.3 ± 220 | 4.7 ± 2.1 | 5.9 ± 2 | 2,650 ± 1,188 | 10.2 ± 2.4 | 76.5 ± 66.8 | 2.7 ± 2.3 |
| Relative bioavailability | 10.8 |
1
Maximal concentration.
2
Time to maximal concentration.
3
Area under the time concentration curve.
4
Mean residence time.
5
Apparent volume of distribution not corrected for bioavailability.
6
Clearance not corrected for bioavailability.
†
Indicates a statistically significant difference between the groups.
*
Nonparametric data, median (IQR) = 65 (31–589). For comparison Cmax Fed Median (IQR) = 503 (266.2, 660).
**
Nonparametric data, median (IQR) = 321 (224–1,709). For comparison AUC Fed, Median IQR = 2816 (1763, 3160).