Table 2.
Summary of the current and previously reported pharmacokinetic parameters for single dose of CBD administered to cats.
| Parameter | Present study Mean ±SD | Present study Mean ±SD Fed | Wang et al. (28) 24 h Mean ±SD | Deabold et al. (27) Mean ±SEM | Rozental et al. (29) Mean (Range) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number of cats in study group | n = 8 | n = 8 | n = 8 | n = 5 | n = 4 | n = 4 | n = 4 | n = 4 | n = 4 | n = 4 |
| Dose mg/kg | 5 | 5 | 1.37 ± 0.15 | 2 | 2.5 | 5 | 10 | 20 | 40 | 80 |
| Cmax (ng/mL) | 269 ± 334 *65 (16.9–865.1) | 465.3 ± 220 | 282 ± 149.4 | 43 ± 9 | 17.8 (3.2–45.3) | 61.1 (19.9–148.5) | 132.6 (43.2–258.4) | 281.0 (14.5–467.4) | 251.7 (47.4–467.0) | 963.9 (744.6–1126.8) |
| Tmax (hours) | 2.6 ± 1.6 | 4.7 ± 2.1 | 2 ± 0 | 2.0 ± 0.6 | *2.0 (2.0–4.0) | *2.0 (2.0–4.0) | *2.0 (2.0–24.0) | *2.0 (2.0–4.0) | *2.0 (2.0) | *3.0 (2.0–6.0) |
| Disapperance Half Life (hours) | 4.1 ± 4.4 | 5.9 ± 2 | 2.1 ± 1.1 | 1.5 ± 0.1 | 13.2 (12.8–13.5) | 8.2 (6.0–11.0) | 7.5 (6.2–8.5) | 9.0 (5.7–14.9) | 9.6 (6.3–17.7) | 6.7 (6.6–6.7) |
| AUC (ng*h/mL) | 921 ± 1,003 *321 (161.9–2,858.5) | 2,650 ± 1,188 | 908.5± 528.1 | 164 ± 29 | 83.5 (8.1–165.9) | 437.1 (180.0–1,139.2) | 1,000.4 (460.8–1,714.1) | 1,481.0 (92.9–2,372.9) | 1,945.8 (313.1–4,150.1) | 8,738.1 (4,269.6–10,690.0) |
| MRT (h) | 12.1 ± 7.5 | 10.2 ± 2.4 | 3.8 ± 1.0 | 3.5 ± 1.4 | 4.5 (2.2–8.5) | 7.0 (5.9–8.1) | 9.0 (7.0–13.9) | 6.3 (7.2–8.1) | 7.5 (8.1–15.1) | 8.4 (7.6–9.4) |
| VdF (L/kg) | 668.3 ± 1,130 | 76.5 ± 66.8 | Not reported | Not Reported | 239.7 (239.6–239.8) | 196.9 (50.2–344.7) | 110.1 (65.1–179.1) | 886.6 (73.1–3246.3) | 702.0 (89.0–2152.5) | 68.3 (65.8–70.9) |
| CL/F (L/h/kg) | 16 ± 10.1 | 2.7 ± 2.3 | Not reported | Not Reported | 12.6 (12.3–13.0) | 17.4 (3.7–23.1) | 11.1 (5.3–20.2) | 45.2 (8.5–84.6) | 37.3 (7.7–71.8) | 7.13 (6.8–7.5) |