Table 5.

The docking binding free energies of the synthesised compounds against EGFR^WT and EGFR^T790M.

Comp.	Binding free energy (kcal/mol)
	EGFRWT	EGFRT790M
5a	−17.54	−16.01
5b	−17.22	−16.08
5c	−18.64	−17.27
5d	−17.41	−16.27
6	−18.81	−17.61
7a	−15.02	−12.95
5e	−19.84	−16.11
5f	−17.49	−17.37
7b	−12.87	−12.29
8	−26.27	−21.08
Erlotinib	−23.94	–
TAK-285	–	−21.55