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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: J Am Coll Cardiol. 2023 Feb 21;81(7):623–632. doi: 10.1016/j.jacc.2022.11.051

TABLE 1.

Harrell’s C-Statistics of 10-Year and 30-Year Cardiovascular Risk Prediction Tools

Prediction Harrell’s C-Statistic (95% CI) Difference (95% CI)

10-year risk 0.726 (0.689 to 0.765) Reference
30-year risk
 Hard ASCVD outcome model (without BMI)a 0.749 (0.714 to 0.784) 0.023 (−0.005 to 0.047)
 Hard ASCVD outcome model (with BMI) 0.738 (0.704 to 0.775) 0.011 (−0.018 to 0.040)
 Expanded CVD outcome model (without BMI) 0.755 (0.720 to 0.789) 0.028 (0.001 to 0.053)b
 Expanded CVD Outcome Mode (with BMI) 0.740 (0.705 to 0.776) 0.014 (−0.016 to 0.043)

See Supplemental Table 1 for risk factors and outcomes used for each risk prediction.

a

Primary analysis.

b

Statistically significant.

ASCVD = atherosclerotic cardiovascular disease; BMI = body mass index; CVD = cardiovascular.