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. 2023 May 23;15(11):2880. doi: 10.3390/cancers15112880

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Receiver operating characteristic (ROC) curves and Matthews correlation coefficient (MCC) cut-off point analysis of ER+/ER+ and HER2+ classifiers. Training/validation: 5-fold cross-validation, consideration of cluster correlation, sample size of 329 metastases. Independent test/validation set: sample size of 83 metastases. Crosses depict the maximum MCC cut-off points. ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; AUC, area under the curve; CI, confidence interval.