Table 3.

Analysis of 3 orthologs with significant differences between cancer patients and control groups.

Function Name	Abundance Median			Fold Change	Univariate Logistic Regression	OR (95% CI) b	p Value c	AUC
	Control (n = 750)	Cancer (n = 313)	p Value a	Cancer/ Control
G protein-coupled receptor kinase (K08291)	3.1 × 10−8	1.7 × 10−7	1.5 × 10−16	5.40	Continuous Scale	1.75 (1.54–1.98)	7.2 × 10−18	0.73
					Quartile 1	ref	7.1 × 10−25
					Quartile 2	1.37 (0.87–2.15)
					Quartile 3	2.34 (1.57–3.49)
					Quartile 4	3.13 (2.20–4.45)
Futalosine hydrolase (K11783)	2.3 × 10−8	1.2 × 10−7	6.9 × 10−8	5.20	Continuous Scale	1.39 (1.24–1.56)	1.9 × 10−8	0.76
					Quartile 1	ref	6.8 × 10−19
					Quartile 2	2.35 (1.58–3.51)
					Quartile 3	3.06 (2.09–4.48)
					Quartile 4	4.61 (3.24–6.57)
H+-transporting ATPase (K01535)	5.1 × 10−8	2.5 × 10−7	8.5 × 10−23	5.00	Continuous Scale	1.74 (1.56–1.94)	1.2 × 10−23	0.73
					Quartile 1	ref	3.1 × 10−25
					Quartile 2	1.66 (1.07–2.60)
					Quartile 3	1.78 (1.15–2.76)
					Quartile 4	6.74 (4.71–9.66)

^a p value was computed using Wilcoxon rank-sum test for continuous variables. ^b quartiles of each genus were divided based on the distribution among controls only. ^c p value was computed using chi-square test for continuous scale and quartiles. OR: Odds ratio. 95% CI: Confidence interval.