. 2023 May 23;15(11):2872. doi: 10.3390/cancers15112872

Table 2.

Types of targeted therapies against breast cancer.

Type	Molecular Target	Chemotherapeutic	Type of Patient
Angiogenic	VEGF-A	Bevacizumab	HER2-
CDK4/6 inhibitor	CDK4/6	Palbociclib Ribociclib Abemaciclib	HER2+ or HER2-
PI3K/Akt/mTOR pathway inhibitors	PI3K	Alpelisib	Hormone-receptor-positive and HER2-positive
PI3K/Akt/mTOR pathway inhibitors	mTORC1	Everolimus	Advanced hormone-receptor-positive and HER2-positive
PARP inhibitors	PARP	Olaparib	HER2- and BRCA-mutated breast cancer
PARP inhibitors	PARP	Talazoparib	HER2- and locally advanced tumors or with mutations in BRCA