Table 3.
Comparisons of thyroglobulin, TSH at multiple time points and 131I administered activity among five groups of patients.
| ND Median (95%CI) (Min to Max) |
DD Median (95%CI) (Min to Max) |
R Median (95%CI) (Min to Max) |
NED-I Median (95%CI) (Min to Max) |
NED-L Median (95%CI) (Min to Max) |
p | |
|---|---|---|---|---|---|---|
| Tg−30 (ng/mL) | 3.50 (1.62 to 5.00) (1.30 to 8.60) |
28.80 (16.00 to 189.00) (16.00 to 189.00) |
1.50 (0.40 to 2.93) (0.30 to 2.93) |
0.47 (0.30 to 0.64) (0.09 to 1.50) |
0.48 (0.30 to 0.63) (0.00 to 1.45) |
<0.0001 |
| Tg0 (ng/mL) | 15.26 (5.92 to 38.43) (0.97 to 64.00) |
159.40 (33.00 to 2095.00) (33.00 to 2095.00) |
7.82 (0.98 to 149.00) (0.61 to 149.00) |
1.38 (0.59 to 2.20) (0.00 to 25.31) |
1.59 (0.43 to 3.08) (0.00 to 81.90) |
<0.0001 |
| Tg0H | 33.70 (2.49 to 64.00) (2.49 to 64.00) |
359.00 (159.40 to 2095.00) (159.40 to 2095.00) |
74.99 (0.98 to 149.00) (0.49 to 149.00) |
1.97 (0.30 to 6.54) (0.00 to 14.68) |
2.73 (1.33 to 4.80) (0.00 to 39.80) |
0.002 |
| Tg0TSH | 7.41 (0.97 to 38.43) (0.97 to 38.43) |
59.24 (33.00 to 85.49) (33.00 to 85.49) |
7.15 (0.61 to 20.32) (0.61 to 20.32) |
0.59 (0.00 to 3.07) (0.00 to 25.31) |
0.44 (0.23 to 3.08) (0.00 to 81.90) |
0.004 |
| p | 0.11 | 0.15 | 0.84 | 0.21 | 0.08 | |
| Tg+7 (ng/mL) | 82.00 (40.00 to 308.50) (0.69 to 515.00) |
169.70 (100.00 to 900.00) (100.00 to 900.00) |
13.70 (1.91 to 211.20) (1.91 to 211.20) |
23.81 (5.60 to 50.60) (0.00 to 99.40) |
18.58 (7.39 to 37.00) (0.00 to 872.00) |
0.005 |
| Tg+7H | 85.95 (40.00 to 515.00) (40.00 to 515.00) |
534.85 (169.70 to 900.00) (169.70 to 900.00) |
139.50 (88.00 to 191.00) (88.00 to 191.00) |
33.85 (4.43 to 96.50) (0.00 to 99.40) |
36.40 (6.39 to 78.70) (0.00 to 283.00) |
0.036 |
| Tg+7TSH | 78.99 (0.69 to 183.00) (0.69 to 183.00) |
100.00 (100.00 to 100.00) (100.00 to 100.00) |
11.46 (1.91 to 211.20) (1.91 to 211.20) |
18.42 (0.54 to 50.60) (0.00 to 211.20) |
12.80 (5.12 to 35.00) (0.00 to 872.00) |
0.37 |
| p | 0.08 | 0.54 | 0.33 | 0.24 | 0.36 | |
| TSH−30 (mIU/L) | 0.49 (0.13 to 0.80) (0.00 to 0.87) |
0.50 (0.08 to 1.26) (0.08 to 1.26) |
0.45 (0.07 to 1.35) (0.04 to 1.35) |
0.11 (0.09 to 0.25) (0.00 to 0.71) |
0.17 (0.12 to 0.21) (0.00 to 1.34) |
0.14 |
| TSH0 (mIU/L) | 101.67 (79.29 to 138.38) (26.51 to 160.97) |
102.86 (64.30 to 244.41) (64.30 to 244.41) |
171.61 (79.34 to 498.00) (43.33 to 498.00) |
106.59 (82.74 to 121.00) (36.20 to 232.43) |
98.59 (84.18 to 116.10) (20.28 to 299.23) |
0.32 |
| Activity (mCi) | 120 (100 to 120) (30 to 150) |
150 (100 to 150) (100 to 150) |
100 (80 to 150) (50 to 150) |
100 (100 to 120) (50 to 120) |
80 (80 to 100) (50 to 150) |
<0.0001 |
| Activity (MBq) | 4440 (3700 to 4440) (1110 to 5550) |
5550 (3700 to 5550) (3700 to 5550) |
3700 (2960 to 5550) (1850 to 5550) |
3700 (1850 to 4440) (3700 to 4440) |
2960 (2960 to 3700) (1850 to 5550) |
<0.0001 |
Abbreviations: ND = hodal disease; DD = distant disease; R = biochemical indeterminate—minimal residual tissue; NED-I = non-evidence of disease—ATA intermediate risk; NED-L = non-evidence of disease—ATA low risk Tg−30 = thyroglobulin 30 days before 131I; Tg0 = thyroglobulin at 131I; Tg0H = Tg in hypothyroidism; Tg0TSH = Tg after rhTSH; Tg+7 = thyroglobulin 7 days after 131I; Tg+7H = Tg in hypothyroidism 7 days after 131I; Tg+7TSH = Tg after rhTSH 7 days after 131I; TSH−30 = thyrotropin before 131I; TSH0 = thyrotropin at 131I. Post hoc analysis: Tg−30 = (ND vs. DD), p = 0.009; (ND vs. NED-I), p < 0.0001; (ND vs. NED-L), p < 0.0001; (DD vs. R), p = 0.03; (DD vs. NED-I), p = 0.004; (DD vs. NED-L), p = 0.002; Tg0 = (ND vs. DD) p = 0.03; (ND vs. NED-I) p = 0.0004; (ND vs. NED-L) p = 0.0007; (DD vs. NED-I) p = 0.004; (DD vs. NED-L) p = 0.002; Tg0H = (ND vs. NED-I) p = 0.02; (ND vs. NED-L) p = 0.036; (DD vs. NED-L) p = 0.038; Tg0TSH = (ND vs. DD) p = 0.0007; (DD vs. R) p = 0.0002; (DD vs. NED-I) p < 0.0001; (DD vs. NED-L) p < 0.0001; Tg+7 = (ND vs. NED-I) p = 0.02; (ND vs. NED-L) p = 0.035; (DD vs. NED-I) p = 0.04; Tg+7H = (ND vs. DD) p = 0.01; (DD vs. NED-I) p = 0.0001; (DD vs. NED-L) p < 0.0001; Activity = (ND vs. NED-L) p = 0.001; (DD vs. NED-L) p = 0.007; (NED-I vs. NED-L) p = 0.0001.