Table 2.
Paper | Procedure | Dataset | Sensitivity (%) | Specificity (%) | Other (%) | Autofluorescence of PGs | Time for PG Identification by NIFI |
---|---|---|---|---|---|---|---|
Kim S W 2016 [104] | Thyroidectomy | 16 PGs 8 patients |
W | Mean P/B 2.76 P/B 1.95–5.20 |
Before operation 5–10 min During operation <1 min |
||
Kim S W 2017 [105] | Thyroidectomy | 70 PGs 38 patients |
100 | 100 | PPV: 100 NPV: 100 AC: 100 |
Mean P/B 4.78 P/B 1.96–12.21 |
Before operation 10 min During operation 2–3 min |
Ladurner R 2018 [106] | Thyroidectomy | 41 PGs 20 patients |
90 | Extra 10 min of operating time |
|||
Takahashi T 2020 [107] | Thyroidectomy |
41 PGs 36 patients |
82.9 | ||||
Kose E 2019 [111] |
Thyroidectomy Parathyroidectomy |
971 specimens 310 patients |
98 | Mean P/B 1.73 | During operation <1 min |
||
550 specimens additionally sent to pathology | 98.5 | 97.2 | PPV: 95.1 NPV: 99.1 AC: 97.6 |
||||
Falco J 2016 [112] |
Thyroidectomy Parathyroidectomy |
28 patients | Mean 40.6 14.1–67.1 |
||||
McWade WM 2016 [113] |
Thyroidectomy Parathyroidectomy |
264 PGs 137 patients |
97 | P/B 1.2–29 | Approximately extra 3–4 min of operating time | ||
Kahramangil B 2018 [114] | Thyroidectomy Parathyroidectomy |
594 PGs 210 patients |
98 | Approximately extra 4 min of operating time |
|||
Kim D H 2021 * [115] | Thyroidectomy Parathyroidectomy |
17 studies with 1198 participants | 96.93 | 92.48 | NPV: 95.17 PPV: 94.88 |
PG—parathyroid gland, PPV—positive predictive value, NPV—negative predictive value, AC—accuracy, P/B—parathyroid to background fluorescence ratio, *—systematic review and meta-analysis.