ADM	Acinar-Ductal Metaplasia
αKG	α-ketoglutarate
AKT	Protein Kinase B
apCAFs	Antigen-Presenting Cancer-Associated Macrophages
APCs	Antigen-Presenting Cells
ARID1A	AT-rich interactive domain-containing protein 1A
α-SMA	α-Smooth Muscle Actin
BM	Bone Marrow
B-reg	Regulatory B Lymphocytes
C1Q	complement component 1q
CAFs	Cancer-Associated Fibroblasts
CAR-T	chimeric antigen receptor T-cell therapy
CAR-M	chimeric antigen receptor macrophages therapy
CARTmeso cells	Mesothelin-directed CAR-T cells
CCL2	C-C Chemokine Ligand
CD	Cluster of Differentiation
CD133	Prominin1
CDKN2A	cyclin-dependent kinase inhibitor 2A
CEA	Carcinoembryonic Antigen
CEACAM	CEA-related cell adhesion molecule
CICs	Cancer Inducing Cells
Col1a1	Collagen, type I, alpha 1
Co-SMAD	co-mediator SMAD
csCAFs	Complement-Secreting Cancer-Associated Macrophages
CTLs	Cytotoxic T Lymphocytes
CXCL	C-X-C motif Chemokine ligand
DCs	Dendritic Cells
ECM	Extracellular Matrix
EMT	Epithelial-Mesenchymal Transition
ERK	Extracellular signal-regulated kinase
EVs	Extracellular Vesicles
FAP	Fibroblast Activation Protein
FGF	Fibroblasts Growth Factor
FOXP3	Forkhead box P3
FSP-1	Fibroblast Surface Protein 1
GAGs	glycosaminoglycans
GM-CSF	Granulocyte-Macrophage Colony Stimulating Factor
GREM1	Gremlin 1
HRAS	Harvey rat sarcoma viral
HLA	Human Leukocyte Antigen
HLA-DR	Human Leukocyte Antigen-DR isotype
iCAFs	Inflammatory Cancer-Associated Fibroblasts
IHH	Indian Hedgehog
IL	Interleukin
IPMN	intraductal papillary mucinous neoplasm
KRAS	Kirsten Rat Sarcoma Virus
M-CSF	Macrophage-Colony Stimulating Factor
MAGUK	Membrane-Associated Guanylate Kinase
MCL-1	myeloid cell leukemia-1
MDSCs	Myeloid-Derived Suppressor Cells
MHC	Major Histocompatibility Complex
MIF	Macrophage Migration Inhibiting Factor
MMPs	Matrix Metalloproteinases
MMR	Mismatch Repair
MPP6	MAGUK P55 Subfamily Member
MSCs	Mesenchymal Stem Cells
MVBs	Multivesicular Bodies
MYC	myelocytomatosis oncogene
myCAFs	Myofibroblastic Cancer-Associated Macrophages
NETs	Neutrophil Extracellular Traps
NRAS	(Neuroblasoma rat sarcoma viral
NK	Natural Killer
NLRP3	NLR family pyrin domain containing 3
Onf-FN	oncofetal Fibronectin
PanIN	Pancreatic Intraepithelial Neoplasia
PB	Peripheral Blood
PC	Pancreatic Cancer
PCCs	Pancreatic Cancer Cells
PDAC	Pancreatic Ductal Adenocarcinoma
PDGFR	Platelet-derived growth factor receptor
PD-L1	Programmed death-ligand 1
PI3K	phosphatidylinositol-3 kinase
pp-GalNAc-T6	UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6
PSCs	Pancreatic Stellate Cells
RAF	rapidly accelerated fibrosarcoma
RANTES	Regulated on Activation, Normal T Cell Expressed and Secreted
R-SMAD	receptor-regulated SMAD
R0	resections: no cancer cells present microscopically at the primary tumor site
ROS	Reactive Oxygen Species
Saa3	Serum Amyloid A 3
SBE	SMAD Binding Element
SHH	Sonic Hedgehog
SMAD	Small Mother Against Decapentaplegic
TAMs	Tumour-Associated Macrophages
TCA	Tricarboxylic Acid
TET	ten-eleven translocation methylcytosine dioxygenases
TEXs	Tumor-Derived Exosomes
TGF-β	Transforming Growth Factor β
TGFβR	Transforming Growth Factor β Receptor
TLR	Toll-Like Receptor
TME	Tumour Microenvironment
TNF-α	Tumor Necrosis Factor alpha
TP53	Tumour Protein 53
T-reg	Regulatory T Lymphocytes
VEGF	Vascular Endothelial Growth Factor
YAP	Yes-associated protein