Table 3.

Behaviorally relevant allele variant associations with cancer risk when osteosarcoma is excluded (p-values). Each of these assessments evaluates the joint effect of the specific allele, cancer type, dog size, and lifespan effects. In this table, n corresponds to the individual breed observations across studies. Significant effects are labeled with an asterisk (*).

		Not Including Osteosarcoma
Position (CanFam3.1)	Allele	All Breeds in Studies Included n = 88, 35 Breeds				Singleton Breeds in Studies Removed n = 74, 30 Breeds
		Allele Effect	Cancer Type Effect	Dog Size Effect	Lifespan Effect	Allele Effect	Cancer Type Effect	Dog Size Effect	Lifespan Effect
chr1:42035784	AA	0.9614	0.0304 *	0.1957	0.8151	0.7807	0.0371 *	0.3545	0.9966
	AB	0.4069	0.0279 *	0.2146	0.8440	0.2115	0.0310 *	0.4202	0.9253
	BB	0.3668	0.0232 *	0.1578	0.9201	0.3475	0.0262 *	0.2582	0.8987
chr1:93250465	AA	0.5405	0.0346 *	0.2364	0.8897	0.5090	0.0410 *	0.3907	0.9157
	AB	0.0159 *	0.0115 *	0.2080	0.9006	0.0247 *	0.0198 *	0.3986	0.8873
	BB	0.0514 *	0.0208 *	0.2627	0.9693	0.0652	0.0302 *	0.4548	0.8302
chr10:2431382	AA	0.0009 *	0.0144 *	0.7134	0.2411	0.0009 *	0.0104 *	0.9130	0.1177
	AB	0.0041 *	0.0113 *	0.3886	0.6198	0.0020 *	0.0068 *	0.7950	0.2991
	BB	0.0029 *	0.0306 *	0.8166	0.2021	0.0050 *	0.0260 *	0.9996	0.1564
chr10:7996770	AA	0.6705	0.0301 *	0.2020	0.8318	0.6814	0.0365 *	0.3255	0.9900
	AB	0.6786	0.0279 *	0.2072	0.8753	0.6660	0.0331 *	0.3286	0.9453
	BB	0.8310	0.0344 *	0.1904	0.7956	0.8642	0.0401 *	0.3204	0.9836
chr10:8059173	AA	0.0953	0.0260 *	0.1718	0.5862	0.1433	0.0404 *	0.3469	0.8050
	AB	0.2891	0.0311 *	0.2048	0.8703	0.2016	0.0280 *	0.3586	0.9111
	BB	0.0171 *	0.0256 *	0.1812	0.5515	0.0165 *	0.0328 *	0.4171	0.7676
chr10:8397696	AA	0.0170 *	0.0166 *	0.1383	0.8919	0.0369 *	0.0269 *	0.2735	0.9248
	AB	0.0099 *	0.0128 *	0.1213	0.7306	0.0113 *	0.0180 *	0.2334	0.9045
	BB	0.1922	0.0271 *	0.1785	0.9182	0.3564	0.0364 *	0.3177	0.9201
chr10:8454499	AA	0.0093 *	0.0551	0.0783	0.7428	0.0155 *	0.0611	0.1576	0.9486
	AB	0.2677	0.0575	0.1956	0.7517	0.1653	0.0675	0.3323	0.9434
	BB	0.0441 *	0.0774	0.1351	0.7117	0.0358 *	0.0831	0.2352	0.9209
chr13:8391652	AA	0.1529	0.0361 *	0.1759	0.9763	0.0966	0.0297 *	0.3434	0.6313
	AB	0.8148	0.0292 *	0.1889	0.8511	0.4341	0.0269 *	0.3062	0.8642
	BB	0.4456	0.0364 *	0.1894	0.8185	0.6732	0.0405 *	0.3297	0.9877
chr15:41232547	AA	0.5398	0.0256 *	0.1561	0.7301	0.7833	0.0340 *	0.3029	0.9596
	AB	0.2113	0.0186 *	0.1553	0.7726	0.3720	0.0260 *	0.2803	0.9680
	BB	0.6878	0.0314 *	0.2856	0.9316	0.5230	0.0395 *	0.4903	0.8266
chr15:41250986	AA	0.7143	0.0425 *	0.1871	0.7823	0.5093	0.0422 *	0.3070	0.9427
	AB	0.9493	0.0432 *	0.1901	0.8168	0.6441	0.0496 *	0.3013	0.9895
	BB	0.6454	0.0301 *	0.1954	0.7562	0.6299	0.0333 *	0.3277	0.9361
chr18:20310833	AA	0.4142	0.0363 *	0.2337	0.9995	0.7724	0.0360 *	0.3487	0.9325
	AB	0.7586	0.0288 *	0.1895	0.8365	0.9189	0.0350 *	0.3215	0.9916
	BB	0.4729	0.0426 *	0.2545	0.9940	0.8402	0.0369 *	0.3536	0.9459
chr24:23196435	AA	0.1783	0.0178 *	0.2074	0.8332	0.1178	0.0208 *	0.3532	0.6150
	AB	0.5661	0.0261 *	0.1850	0.8338	0.4624	0.0302 *	0.3132	0.9760
	BB	0.1946	0.0209 *	0.2270	0.7706	0.1507	0.0241 *	0.3769	0.5745
chr24:23398090	AA	0.2807	0.0290 *	0.1293	0.6862	0.3243	0.0333 *	0.2182	0.8575
	AB	0.2244	0.0311 *	0.1282	0.6639	0.2542	0.0365 *	0.2128	0.8292
	BB	0.8011	0.0292 *	0.1825	0.8041	0.8821	0.0348 *	0.3164	0.9940
chr32:5421210	AA	0.0510	0.0207 *	0.2459	0.8443	0.0631	0.0345 *	0.4719	0.6546
	AB	0.3732	0.0297 *	0.2447	0.9410	0.2329	0.0471 *	0.5038	0.6563
	BB	0.0144 *	0.0134 *	0.1604	0.8044	0.0531	0.0214 *	0.2964	0.9951
chr34:18559537	AA	0.3730	0.0263 *	0.2344	0.8631	0.3167	0.0351 *	0.3692	0.9665
	AB	0.3328	0.0251 *	0.2224	0.8444	0.2754	0.0340 *	0.3466	0.9948
	BB	0.6352	0.0299 *	0.2384	0.8722	0.5842	0.0370 *	0.3877	0.9389
chrX:101646292	AA	0.1307	0.0228 *	0.1232	0.4532	0.0877	0.0309 *	0.2608	0.5636
	AB	0.2748	0.0286 *	0.1501	0.9254	0.6502	0.0365 *	0.2863	0.9596
	BB	0.0328 *	0.0191 *	0.0758	0.3922	0.0551	0.0333 *	0.1809	0.5846
chrX:102553876	AA	0.3153	0.0498 *	0.1325	0.6662	0.1410	0.0460 *	0.1485	0.6949
	AB	0.6056	0.0351 *	0.1676	0.7533	0.2291	0.0341 *	0.2026	0.8118
	BB	0.0961	0.1351	0.0948	0.6566	0.1563	0.1055	0.1362	0.7568