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. 2023 Jun 9;14:3417. doi: 10.1038/s41467-023-38682-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Modules that are significantly expressed more highly in clusters 4 and 5 relative to all other clusters. Modules unique to a cluster are arranged and ranked by increasing adjusted p-value of <0.05, while modules expressed in both clusters are arranged and ranked by the average of their adjusted p-values. The color gradient of each node represents the -log10 adjusted p-value. P-values were determined by a two-sided Wilcoxon test. B–D Box and jitter plots of the Single Sample Gene Set Enrichment Analysis (ssGSEA) scores (y-axis) across all clusters (x-axis) (that consist of PASC, n = 55; recovered, n = 24; uninfected, n = 22 participants) for the top-ranked modules that were enriched in inflammatory clusters 4 and 5. P-values determined by a two-sided Wilcoxon test were calculated comparing inflammatory cluster 4 and inflammatory cluster 5 independently to clusters 1,2,3. Box plots show the median (centerline), the first and third quartiles (the lower and upper bound of the box) and the whiskers show the 1.5x interquartile range of the data.