Figure 5.

Effect of Ceramide AD™ on Trans-Epidermal Water Loss. Trans-epidermal water loss (TEWL) was measured in 12 patients with (A) moderately dry skin (TEWL > 5 g/m²/h) (n = 12) at baseline (Day 0) and 2 days (Day 2) after daily topical application of the cream. Change in skin function (TEWL) was also measured (B) in patients with very dry skin (TEWL > 15 g/m²/h), 21 days after daily application of cream on patient’s forearms containing 0.08% Ceramide AD™. The results are represented as change in TEWL from baseline to day 21, in vehicle (black, n = 15) and Ceramide AD™-containing cream (orange, n = 15), with negative values indicating reduced TEWL and hence improved skin function. Differences between groups were assessed using Wilcoxon Signed Rank Test.