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. 2023 May 24;24(11):9177. doi: 10.3390/ijms24119177

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Epigenetic regulation of the gene encoding for Na⁺/Ca²⁺ exchanger isoform 3 (NCX3) following stroke. (1) Experimental stroke injury increases DREAM expression in peri-ischemic temporoparietal cortex region (2); under these conditions, DREAM recruits the epigenetic enzymes histone deacetylase isoform 4 and 5 (HDAC4 and HDAC5), forming a complex (3) that binds to the DRE sequence on ncx3 gene promoter (4); this complex deacetylates lysins of histones on ncx3 promoter and inhibits the expression of ncx3 gene (5); this process ultimately increases neuronal damage following stroke (6).