Table 2.
Summary of all clinical trials run on DBS and AD research. The data were extracted from https://www.clinicaltrials.gov (Accessed on 19 December 2022) with 16 data points returned filtered to 14 research projects upon analysis. Abbreviations used include not disclosed (ND), year of publication (YoP), principal investigator (PI), and not published (NP).
| Brain Region | Laterality | Stimulus Settings | Duration (Months) | Patients | Trial Status | YoP | Author/PI | Reference |
|---|---|---|---|---|---|---|---|---|
| -Fornix | Bilateral | 3.9–7.5 mA, 90 µs, 130 Hz | 24 | 1 | Completed | 2022 | Barcia | [128] |
| -Fornix | ND | 3.0–3.5 V, 90 µs, 130 Hz | 12 | 6 | Completed (phase I) | 2010 | Laxton | [37] |
| -Fornix | Bilateral | 3.0–3.5 V, 90 µs, 130 Hz | 12 | 42 | Completed (phase II) | 2016 | Lozano | [34] |
| -Fornix | ND | ND | 12 | 12 | Active, not Recruiting | NP | Lozano | [129] |
| -ND | Bilateral | ND | 23 | 3 | Completed | NP | Rezai | [130] |
| -ND | ND | ND | 12 | 10 | Recruiting | NP | Luming | [131] |
| -Fornix | Bilateral | 1–5 V, 90 ms, 130 Hz | 12 | 6 | Completed (phase I) | 2018 | Mao | [33] |
| -NBM | Bilateral | 2.0–4.5 V, 90 µs, 20 Hz | 12 | 6 | Completed | 2014 | Kuhn | [38] |
| -NBM | ND | 2.0–4.5 V, 60 µs, 20 Hz | 12 | 30 | Recruiting | NP | Chen | [132] |
| -NBM | Bilateral | ND | ND | 6 | Completed | NP | Sturm | [133] |
| -Hypothalamus-Fornix | Bilateral | 2–3 V, 120 ms, 180 Hz | 24 | 5 | Recruiting | NP | Fontaine | [134] |
| -Fornix | Bilateral | ND | 12 | 6 | Completed | NP | Laxton | [135] |
| -Fornix | ND | ND | 12 | 210 | Recruiting | NP | ND | [136] |
| -Fornix-NBM | ND | ND | 12 | 30 | Recruiting | NP | ND | [137] |