ACE |
angiotensin-converting enzyme |
Agtr1a-/-
|
mutant mice with whole-body deletion of the angiotensin II AT1a receptor |
Ang I |
angiotensin I |
Ang II |
angiotensin II |
AT1 (AT1a) |
type 1 (1a) receptor for Ang II |
AT2
|
type 2 receptor for Ang II |
ECFP |
enhanced cyan fluorescence protein |
ERK1/ERK2 |
extracellular signal-regulated kinase (ERK) 1/2 |
GFR |
glomerular filtration rate |
MAP |
MAP kinase |
mPCT |
mouse proximal tubule cells |
MEK1 |
MAP kinase 1 |
MEK2 |
MAP kinase 2 |
Na+/HCO3-
|
basolateral Na+/HCO3- cotransporter NBCe1-A |
NF-κB |
nuclear factor kappaB |
NHE3 |
the Na+/H+ exchanger 3 |
p-ERK1/2 |
phosphorylated ERK1/2 |
RAS |
the renin-angiotensin system |
SGLT2 |
sodium and glucose cotransporter 2 |
WT |
wild-type mice |