Table 1.
Summary of all behavioral and biochemical/histological results for all mouse lines. All the changes are present compared to LCtrl, and the number of animals per experiment is mentioned. Some animals were excluded in some experiments due to problems in performing. ↑ and ↓, increased or decreased compared to LCtrl; ++, higher expression compared to LCtrl; +, slightly higher expression compared to LCtrls; =, not statistically different compared to LCtrl; N/A, not applicable (experiment not performed in this mouse line); NORT, novel object recognition test; FC, fear conditioning; MWM, Morris water maze; *, experiment performed on [22].
| Therapeutic Treatment | Preventive Treatment | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LCtrl | LCtrl Rol | Tau∆K | Tau∆K Rol | LCtrl | LCtrl Rol | TauRD∆K | TauRD∆K Rol | LCtrl | LCtrl Rol | rTg4510 | rTg4510 Rol | LCtrl | LCtrl Rol | rTg4510 | rTg4510 Rol | ||
| Behavior experiments | Y-maze | - | - | ↓* | ↑* | N/A | N/A | N/A | N/A | (n = 14) | (n = 14) | ↓ (n = 9) | ↓ (n = 9) | N/A | N/A | N/A | N/A |
| NORT | - | - | ↓* | ↑* | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | |
| FC | - | - | ↓* | ↑* | (n = 9) | (n = 11) | ↓ (n = 10) | ↑ (n = 12) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | |
| Body weight | (n = 7) | (n = 9) | ´=(n = 9) | ´=(n = 8) | (n = 9) | (n = 11) | ↓ (n = 10) | ↑ (n = 13) | (n = 12) | (n = 14) | ↓ (n = 10) | ↓ (n = 10) | N/A | N/A | N/A | N/A | |
| Burrowing test | N/A | N/A | N/A | N/A | (n = 9) | (n = 10) | ↓ (n = 10) | ↑ (n = 13) | (n = 14) | (n = 14) | ↓ (n = 9) | ↓ (n = 10) | N/A | N/A | N/A | N/A | |
| Learning MWM | N/A | N/A | N/A | N/A | (n = 9) | (n = 11) | ↓ (n = 10) | ↑ (n = 13) | N/A | N/A | N/A | N/A | (n = 16) | (n = 9) | ↓ (n = 13) | ↓ (n = 13) | |
| LTPT MWM | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (n = 16) | (n = 9) | ´=(n = 13) | ´=(n = 13) | |
| Nesting test | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (n = 14) | (n = 14) | ↓ (n = 9) | ↓↓ (n = 9) | (n = 16) | (n = 9) | ↓ (n = 13) | ↓ (n = 13) (12 h not different than LCtrl) | |
| OF | N/A | N/A | N/A | N/A | (n = 9) | (n = 11) | ´=(n = 10) | ´=(n = 13) | (n = 14) | (n = 14) | ´=(n = 9) | ↑ (n = 9) (hyperactivity) | (n = 16) | (n = 9) | ´=(n = 13) | ´=(n = 13) | |
| OF time in center | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (n = 16) | (n = 9) | ´=(n = 13) | ↓ (n = 13) (anxiety) | |
| Taupathology | Gallyas silver staining | (n =4) | (n = 4) | ++ (n = 4) | + (n = 4) | (n = 4) | (n = 4) | ++ (n = 4) | + (n = 4) | (n = 4) | (n = 4) | ++ (n = 4) | ++ (n = 4) | N/A | N/A | N/A | N/A |
| pTau12E8 | N/A | N/A | ↑ (n = 6) | ↓ (n = 8) | (n = 4) | (n = 4) | ++ (n = 4) | + (n = 4) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | |
| Alz50 | (n = 4) | (n = 4) | ↑ (n = 4) | ↓ (n = 4) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | |
| PHF1 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (n = 4) | (n = 4) | ++ (n = 4) | ++ (n = 4) | N/A | N/A | N/A | N/A | |
| MC1 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (n = 4) | (n = 4) | ++ (n = 4) | ++ (n = 4) | N/A | N/A | N/A | N/A | |
| Synaptic markers | PSD-95 | (n = 6) | (n = 6) | ↓ (n = 6) | ↑ (n = 8) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Spines | (n = 2) | (n = 4) | ↓ (n = 3) | ↑ (n = 3) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | |
| Brain weight/ HIP Volume | (n = 5) | (n = 5) | ´=(n = 6) | ´=(n = 6) | (n = 9) | (n = 10) | ↓ (n = 10) | ↓ (n = 12) | (n = 13) | (n = 13) | ↓ (n = 8) | ↓ (n = 9) | (n = 12) | (n = 9) | ↓ (n = 7) | ↓ (n = 10) | |