Skip to main content
. 2023 May 23;24(11):9151. doi: 10.3390/ijms24119151

Figure 2.

Figure 2

Overview of FUNDC1 regulate mitochondrial quality control (MQC) system. FUNDC1 initiates mitochondrial fission by interacting with DRP1 under stress; under normal conditions, it initiates mitochondrial fusion by interacting with OPA1. Fusion permitted two mitochondrial descendants and their content to mix within a mitochondrial population; FUDNC1 initiates mitophagy by dephosphorylating at Ser13, Try18, and phosphorylating at Ser17, respectively, by protein kinases such as PGAM5, ULK1, and Src kinases.