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. 2023 May 23;24(11):9163. doi: 10.3390/ijms24119163

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Relief from neuroinflammation from COX-2 inhibiting theranostic nanoemulsion in females causes differential gene expression in the affected DRG. (a) For visual clarity, the volcano plot features all of the differentially expressed genes due to relief of neuroinflammation in the female DRG and highlights the top 6 significantly up-regulated (red) and top 10 significantly down-regulated genes (black). (b) Metascape enrichment analysis of the down-regulated biological pathways following reduction of neuroinflammation resulting from COX-2 inhibition.