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. 2023 May 23;24(11):9163. doi: 10.3390/ijms24119163

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Relief from neuroinflammation by COX-2 inhibiting theranostic nanoemulsion in males causes differential gene expression in the affected DRG. (a) For visual clarity, the volcano plot features all the differentially expressed genes due to neuroinflammatory relief in the male DRG with a highlight of the top 10 significantly up-regulated (red) and top 10 significantly down-regulated genes (black). (b) Metascape enrichment analysis of the top 20 up-regulated biological pathways following neuroinflammatory reduction via COX-2 inhibition. (c) Metascape enrichment analysis of the 9 down-regulated biological pathways following reduction of neuroinflammation resulting from COX-2 inhibition.