Table 5.
Multiple miRNAs/miRNA signatures that mediate MSC-based regenerative/healing applications.
| miRNAs | Tissue Origin | Vehicle Type | Target (Gene/Pathway) | Function | Clinical Application | Reference |
|---|---|---|---|---|---|---|
| miR-199a-3p/145-5p | UCMSCs | Exosomes | Cblb, Cbl, NGF/TrkA | Neuronal Differentiation Promotion | SCI | [131] |
| miR-let-7a, miR-let-7e | WJMSCs | EVs | Casp3 | Apoptosis Inhibition | Hypoxic-ischemic Brain Injury | [225] |
| miR-21-5p, miR-125b-5p | UCBMSCs | Exosomes | TGF-βI, TGF-βII | Wound Closure Acceleration, Scar Formation Inhibition, Skin/Nerve/Vessel Regeneration | Skin Wound Healing | [190] |
| miR-21, miR-29, miR-221, let-7a | WJMSCs | EVs | BMP, PI3K/AKT | Osteogenic Differentiation/Osteoblast Activity Promotion | Osteoporosis | [226] |
| miR-122-5p, miR-148a-3p, miR-486-5p, miR-let-7a-5p, miR-100-5p | UCMSCs | EVs | PI3K/Akt | Cartilage Degradation/Inflammation Suppression, M2 Macrophage Polarization Promotion | Osteoarthritis | [192] |
| miR-92b-3p, miR-32-5p, let-7b-5p, miR-19a-3p, miR-19b-3p | WJMSCs | Exosomes | DKK3 | Osteochondral Regeneration | Articular Cartilage Defect | [115] |
| miR-23a-3p, miR-221-3p, miR-23b-3p, miR-141-3p, miR-144-3p, miR-200a-3p, miR-454-3p, miR-23c, miR-320b | WJMSCs | Exosomes | CXCL12 | Osteochondral Regeneration | Articular Cartilage Defect | [115] |
| miR-374a-5p, miR-495-3p, miR-323a-3p | WJMSCs | Exosomes | CCL2 | Osteochondral Regeneration | Articular Cartilage Defect | [115] |
| miR-19b-3p, miR-185-5p | WJMSCs | Exosomes | POSTN | Osteochondral Regeneration | Articular Cartilage Defect | [115] |
| let-7e-5p, miR-423-5p, miR-199a-3p, miR-125b-5p, miR-142-3p, miR-92a-3p | WJMSCs | EVs | ECM-receptor interaction, NOTCH, (STAT3, IGF1R) | Proliferation/Migration/M2 Infiltration Promotion, Homeostasis Maintenance, Injury Degradation Suppression | Osteoarthritis | [193] |
| miR-100, miR-146a, (miR-21, miR-221, miR-143) | UCMSCs | Exosomes | - | Cell Cycle/Proliferation Promotion, Apoptosis Inhibition | Vaginal Reconstruction | [227] |
| miR-135b-5p, miR-499a-3p | UCMSCs | Exosomes | MEF2C | Angiogenesis Promotion | Tissue Regeneration | [228] |
| miR-136, miR-494, miR-495 | UCMSCs | Exosomes | - | Biomarkers (Diagnosis, Evaluation) | Pre-Eclampsia | [229] |
| miR-21, miR-146a-5p | UCMSCs | Exosomes | PI3K/mTOR | Fertility Recovery, Oocyte Production Promotion | Premature Ovarian Insufficiency | [230] |
| miR-146a-5p, miR-548e-5p | UCMSCs | Exosomes | NF-κB, AKT, MAPK | Inflammation Suppression, Proliferation/Migration Promotion | Inflammatory Diseases/Preterm Birth | [231] |
| miR-17 Superfamily | WJMSCs, BMMSCs | Exosomes | (BMPR2) | Proliferation Promotion | Pulmonary Hypertension | [174] |
| miR-10a-5p, miR-146a-5 | UCMSCs | Exosomes | VEGF-VEGFR2/AKT, MEK/ERK | Apoptosis Inhibition | Chronic Obstructive Pulmonary Disease | [232] |
| miR-24, miR-199a-5p | WJMSCs | Exosomes | - | Muscle Regeneration | Duchenne Muscular Dystrophy | [233] |
| miR-124, miR-145 | Bone Marrow/Adipose Tissue/Placenta/Umbilical Cord MSCs | - | SCP-1, Sox2 | Migration/Cell Self-Renewal Inhibition | Glioma | [203] |
| let-7a-2-3p, let-7d, let-7e, let-7f, let-7f-1-3p, let-7g, let-7i, let-7i-3p, miR-100, miR-106a, miR-106b, miR-125a-3p, miR-125a-5p, miR-126, miR-146a, miR-17, miR-181a, miR-18b, miR-196a-3p, miR-19a, miR-19b, miR-200b, miR-20a, miR-20b, miR-21, miR-210, miR-25, miR-27a-5p, miR-29b, miR-302a, miR-302b-5p, miR-302c-5p, miR-30c, miR-31, miR-32, miR-335, miR-34a, miR-374a, miR-378 miR-3915, miR-3924, miR-601, miR-622, miR-920, miR-92a, miR-93, miR-98 | WJMSCs | - | - | Wound Healing Promotion | Excisional/Diabetic Wounds | [234] |
UCMSCs: Umbilical Cord-derived Mesenchymal Stem Cells, UCBMSCs: Umbilical Cord Blood-derived Mesenchymal Stem Cells, WJMSCs: Wharton’s Jelly-derived Mesenchymal Stem Cells, MSCs: Mesenchymal Stem Cells EVs: Extracellular Vesicles SCI: Spinal Cord Injury.