Figure 1.

Combined inhibitory effect of 5-FU, OXA, and the XPF–ERCC1 blocker on cell growth in colorectal cancer cells. (A,C) HCT116 and (B,D) SW620 cells were treated with 5-FU, OXA, the XPF–ERCC1 blockers, the 5-FU/XPF–ERCC1 blocker, or the oxaliplatin/XPF–ERCC1 blocker at a constant ratio of 5-FU: XPF–ERCC1 blocker, 1:1 (HCT116 cells) and 1:1 (SW620 cells) for 72 h at different concentrations. Cell growth inhibition was determined by an ATP lite cell proliferation assay. Cell viability (%) = Sample Absorbance/Control Absorbance × 100. IC50 was calculated by Prismed. IC50, half-maximal inhibitory concentration. Data are presented as the mean + standard deviation. All experiments were independently repeated four times.