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. 2023 May 23;24(11):9129. doi: 10.3390/ijms24119129

Table 1.

Characteristics of the 179 candidate SNPs predictive of C-reactive protein levels.

SNP EA OA EAF Beta SE p CHR POS Sample Size Fstats
rs429358 T C 0.844 0.266 0.003 1.00 × 10−200 19 45,411,941 343,524 6647.33
rs7551731 T C 0.670 0.172 0.003 1.00 × 10−200 1 159,694,779 343,524 4673.13
rs7970695 A G 0.624 0.146 0.002 1.00 × 10−200 12 121,423,376 343,524 3544.54
rs2154384 C T 0.631 0.125 0.002 1.00 × 10−200 1 66,108,517 343,524 2550.92
rs12133641 A G 0.590 0.094 0.002 1.00 × 10−200 1 154,428,283 343,524 1507.50
rs1260326 T C 0.393 0.074 0.002 1.00 × 10−200 2 27,730,940 343,524 916.40
rs17616063 A G 0.924 0.126 0.005 2.33 × 10−171 16 51,436,882 343,524 779.55
rs7012637 A G 0.475 0.048 0.002 1.29 × 10−86 8 9,173,209 343,524 389.34
rs4656849 G A 0.601 0.046 0.002 8.39 × 10−79 1 159,723,521 343,524 353.40
rs6734238 G A 0.402 0.043 0.002 7.74 × 10−71 2 113,841,030 343,524 316.80
rs1889316 C T 0.846 0.056 0.003 2.60 × 10−63 1 154,352,017 343,524 282.22
rs56015600 G A 0.630 0.040 0.002 1.48 × 10−58 1 247,601,886 343,524 260.40
rs1800961 C T 0.969 0.105 0.007 2.86 × 10−53 20 43,042,364 343,524 236.15
rs728538 G T 0.167 0.045 0.003 1.65 × 10−43 16 51,205,819 343,524 191.35
rs2239222 G A 0.349 0.034 0.003 4.78 × 10−42 14 73,011,885 343,524 184.66
rs6519133 T C 0.607 0.033 0.002 5.73 × 10−42 22 39,096,602 343,524 184.30
rs1490384 C T 0.502 0.031 0.002 2.73 × 10−38 6 126,851,160 343,524 167.45
rs35371668 T C 0.181 0.041 0.003 6.19 × 10−38 6 32,561,638 343,524 165.82
rs149624078 C T 0.986 0.130 0.010 1.69 × 10−35 15 53,728,710 343,524 154.69
rs11265157 G C 0.260 0.033 0.003 1.05 × 10−33 1 159,224,029 343,524 146.45
rs28929474 C T 0.980 0.100 0.008 2.19 × 10−32 14 94,844,947 343,524 140.42
rs2836881 G T 0.733 0.032 0.003 8.98 × 10−32 21 40,466,299 343,524 137.62
rs469802 A G 0.796 0.035 0.003 1.04 × 10−31 1 91,545,826 343,524 137.33
rs2393794 C T 0.186 0.036 0.003 3.90 × 10−31 12 121,378,976 343,524 134.69
rs75460349 A C 0.976 0.091 0.008 3.77 × 10−30 1 27,180,088 343,524 130.19
rs6486122 T C 0.691 0.029 0.003 1.34 × 10−28 11 13,361,524 343,524 123.09
rs12944581 C G 0.730 0.031 0.003 2.89 × 10−28 17 76,348,830 343,524 121.58
rs12231235 G A 0.573 0.027 0.002 4.96 × 10−28 12 95,857,690 343,524 120.50
rs115785198 T C 0.071 0.051 0.005 1.60 × 10−27 19 45,249,509 343,524 118.18
rs3768321 T G 0.197 0.032 0.003 4.96 × 10−27 1 40,035,928 343,524 115.93
rs7828742 G A 0.598 0.026 0.002 5.94 × 10−27 8 116,960,729 343,524 115.58
rs635634 T C 0.184 0.033 0.003 3.19 × 10−26 9 136,155,000 343,524 112.24
rs1037170 T C 0.722 0.028 0.003 1.64 × 10−25 17 72,702,914 343,524 109.00
rs2246833 T C 0.340 0.026 0.003 1.65 × 10−25 10 91,005,854 343,524 108.99
rs55855238 C T 0.651 0.026 0.003 1.91 × 10−25 18 55,089,715 343,524 108.70
rs204914 T C 0.047 0.059 0.006 3.07 × 10−25 19 45,466,335 343,524 107.75
rs150844304 C A 0.025 0.080 0.008 3.38 × 10−25 15 43,726,625 343,524 107.56
rs10769254 G C 0.810 0.031 0.003 1.79 × 10−24 11 47,362,465 343,524 104.26
rs35511257 C G 0.095 0.043 0.004 2.82 × 10−23 6 32,545,392 343,524 98.80
rs13242809 T A 0.726 0.027 0.003 4.31 × 10−23 7 22,746,564 343,524 97.96
rs62217799 T G 0.657 0.025 0.003 3.98 × 10−22 20 62,347,191 343,524 93.55
rs17138478 A C 0.129 0.034 0.004 5.62 × 10−22 17 36,073,320 343,524 92.87
rs185320691 C G 0.107 0.041 0.004 5.96 × 10−22 6 32,490,292 343,524 92.75
rs4655802 G A 0.410 0.023 0.002 6.11 × 10−22 1 65,888,231 343,524 92.70
rs2395470 A G 0.329 0.024 0.003 1.15 × 10−21 6 31,235,261 343,524 91.44
rs61542988 C T 0.754 0.026 0.003 1.99 × 10−21 7 22,882,291 343,524 90.36
rs1441171 G T 0.476 0.023 0.002 5.17 × 10−21 2 214,033,637 343,524 88.47
rs11777625 C T 0.546 0.022 0.002 8.48 × 10−21 8 126,333,642 343,524 87.50
rs141783576 G C 0.927 0.043 0.005 1.82 × 10−20 6 127,439,897 343,524 85.99
rs687339 C T 0.228 0.026 0.003 3.07 × 10−20 3 135,932,359 343,524 84.95
rs2847289 C A 0.572 0.022 0.002 3.36 × 10−20 18 12,812,167 343,524 84.78
rs73001065 C G 0.071 0.043 0.005 3.99 × 10−20 19 19,460,541 343,524 84.43
rs112875651 G A 0.607 0.022 0.002 1.32 × 10−19 8 126,506,694 343,524 82.08
rs12496226 T G 0.321 0.023 0.003 1.37 × 10−19 3 49,734,040 343,524 82.01
rs2161037 A G 0.545 0.022 0.002 2.32 × 10−19 2 169,893,419 343,524 80.96
rs2700938 C T 0.376 0.022 0.002 3.78 × 10−19 7 36,085,142 343,524 79.99
rs7846549 G A 0.896 0.035 0.004 4.09 × 10−19 8 9,239,371 343,524 79.83
rs714052 A G 0.875 0.031 0.004 3.38 × 10−18 7 72,864,869 343,524 75.66
rs7357754 G A 0.500 0.021 0.002 4.14 × 10−18 9 92,207,308 343,524 75.26
rs12300845 G T 0.967 0.058 0.007 4.55 × 10−18 12 24,195,798 343,524 75.07
rs77704739 T C 0.958 0.051 0.006 6.65 × 10−18 5 52,080,909 343,524 74.33
rs8178824 T C 0.030 0.060 0.007 1.31 × 10−17 17 64,224,775 343,524 72.99
rs9638882 C A 0.791 0.024 0.003 1.24 × 10−16 7 1,023,617 343,524 68.56
rs11118625 A G 0.731 0.022 0.003 4.12 × 10−16 1 221,103,388 343,524 66.18
rs28429148 A G 0.434 0.020 0.002 4.60 × 10−16 16 53,798,319 343,524 65.97
rs6961634 G A 0.851 0.027 0.003 6.82 × 10−16 7 99,181,839 343,524 65.19
rs1800693 T C 0.599 0.020 0.002 7.10 × 10−16 12 6,440,009 343,524 65.11
rs11605427 G C 0.598 0.020 0.002 8.26 × 10−16 11 59,928,672 343,524 64.81
rs340023 T C 0.269 0.022 0.003 8.45 × 10−16 15 60,908,082 343,524 64.77
rs9604045 G T 0.750 0.023 0.003 1.36 × 10−15 13 113,927,208 343,524 63.84
rs1933736 C T 0.401 0.019 0.002 6.28 × 10−15 6 116,387,255 343,524 60.81
rs704017 A G 0.428 0.019 0.002 1.36 × 10−14 10 80,819,132 343,524 59.29
rs34139656 G A 0.328 0.020 0.003 1.39 × 10−14 16 88,534,923 343,524 59.26
rs8060025 T G 0.389 0.019 0.002 3.87 × 10−14 16 27,327,214 343,524 57.24
rs11145763 C A 0.433 0.018 0.002 4.16 × 10−14 9 139,263,596 343,524 57.09
rs9738365 A C 0.267 0.020 0.003 5.94 × 10−14 12 31,997,635 343,524 56.40
rs2049045 G C 0.813 0.023 0.003 7.03 × 10−14 11 27,694,241 343,524 56.06
rs7084062 G A 0.489 0.018 0.002 8.85 × 10−14 10 133,736,636 343,524 55.61
rs6920220 A G 0.223 0.021 0.003 9.11 × 10−14 6 138,006,504 343,524 55.56
rs4764939 C T 0.531 0.018 0.002 9.33 × 10−16 12 103,522,952 343,524 55.51
rs519790 G C 0.342 0.019 0.003 1.34 × 10−13 11 72,504,141 343,524 54.79
rs6905544 G A 0.600 0.018 0.002 1.51 × 10−13 6 98,411,631 343,524 54.56
rs34298354 C T 0.878 0.027 0.004 1.97 × 10−13 1 247,588,053 343,524 54.04
rs3935032 C T 0.623 0.018 0.003 1.98 × 10−13 1 1,564,194 343,524 54.03
rs1905505 A G 0.284 0.019 0.003 2.06 × 10−13 3 170,695,426 343,524 53.95
rs2250010 T C 0.810 0.022 0.003 2.72 × 10−13 12 47,193,818 343,524 53.41
rs73656635 A C 0.154 0.024 0.003 8.63 × 10−13 9 104,117,630 343,524 51.14
rs799260 G A 0.834 0.023 0.003 9.08 × 10−13 12 56,921,304 343,524 51.04
rs185575165 A T 0.280 0.019 0.003 1.06 × 10−12 18 57,863,231 343,524 50.73
rs4704093 G T 0.468 0.017 0.002 1.27 × 10−12 5 72,976,175 343,524 50.38
rs1476698 G A 0.369 0.018 0.002 1.28 × 10−12 2 242,296,449 343,524 50.37
rs1800919 A C 0.237 0.020 0.003 2.27 × 10−12 2 102,759,293 343,524 49.24
rs17652767 G A 0.894 0.027 0.004 3.48 × 10−12 15 53,169,284 343,524 48.40
rs2161374 C T 0.513 0.017 0.002 4.28 × 10−12 5 172,176,886 343,524 47.99
rs112303588 C G 0.033 0.049 0.007 4.51 × 10−12 12 121,706,242 343,524 47.89
rs17781691 A G 0.506 0.017 0.002 4.56 × 10−12 14 73,366,493 343,524 47.87
rs7311631 A G 0.507 0.016 0.002 5.05 × 10−12 12 90,429,028 343,524 47.67
rs12540285 A G 0.780 0.020 0.003 6.43 × 10−12 7 15,031,2474 343,524 47.19
rs1545536 C T 0.780 0.020 0.003 8.01 × 10−12 8 144,643,169 343,524 46.77
rs4018180 G A 0.932 0.033 0.005 8.05 × 10−12 16 2,169,458 343,524 46.75
rs10760691 G A 0.383 0.017 0.003 8.90 × 10−12 9 102,281,383 343,524 46.56
rs4790286 T A 0.781 0.020 0.003 1.30 × 10−11 17 1,652,483 343,524 45.81
rs1985157 C T 0.413 0.016 0.002 1.68 × 10−11 19 18,513,594 343,524 45.31
rs6792725 A G 0.307 0.018 0.003 1.96 × 10−11 3 24,520,283 343,524 45.02
rs1348675 A G 0.233 0.019 0.003 2.12 × 10−11 13 58,712,638 343,524 44.86
rs4609871 T C 0.552 0.016 0.002 2.66 × 10−11 16 29,932,064 343,524 44.41
rs12132412 G A 0.388 0.016 0.002 3.38 × 10−11 1 21,820,042 343,524 43.94
rs79225028 C G 0.895 0.026 0.004 3.58 × 10−11 12 120,869,983 343,524 43.83
rs2050392 G A 0.388 0.016 0.002 4.16 × 10−11 10 30,691,503 343,524 43.54
rs7652415 T C 0.128 0.023 0.004 5.19 × 10−11 3 9,505,238 343,524 43.11
rs1883711 C G 0.031 0.046 0.007 5.31 × 10−11 20 39,179,822 343,524 43.06
rs2110944 C T 0.531 0.016 0.002 5.91 × 10−11 2 37,090,233 343,524 42.85
rs72694393 G T 0.519 0.016 0.002 6.38 × 10−11 14 24,874,193 343,524 42.71
rs6083801 C T 0.473 0.016 0.002 6.53 × 10−11 20 25,307,574 343,524 42.66
rs57014345 G T 0.602 0.016 0.002 6.60 × 10−11 6 7,010,430 343,524 42.64
rs11850396 G A 0.640 0.016 0.002 7.13 × 10−11 14 96,919,620 343,524 42.49
rs7956514 G T 0.287 0.017 0.003 1.16 × 10−10 12 12,879,254 343,524 41.53
rs12941913 T C 0.608 0.016 0.002 2.12 × 10−10 17 1,346,417 343,524 40.35
rs762360 C T 0.301 0.017 0.003 2.49 × 10−10 21 37,425,955 343,524 40.04
rs60987662 G A 0.380 0.015 0.002 3.52 × 10−10 7 101,844,851 343,524 39.37
rs653170 T C 0.359 0.016 0.002 3.96 × 10−10 1 112,328,245 343,524 39.14
rs142296998 A G 0.006 0.100 0.016 4.28 × 10−10 20 60,888,267 343,524 38.98
rs10175899 A T 0.673 0.016 0.003 5.76 × 10−10 2 113,801,150 343,524 38.40
rs6012927 G A 0.358 0.016 0.003 6.05 × 10−10 20 49,036,638 343,524 38.31
rs11577023 T C 0.690 0.016 0.003 6.12 × 10−10 1 222,061,973 343,524 38.29
rs7563362 G A 0.858 0.021 0.003 8.01 × 10−10 2 620,297 343,524 37.76
rs10831676 A C 0.539 0.015 0.002 8.39 × 10−10 11 11,820,449 343,524 37.67
rs13013 A C 0.584 0.015 0.002 9.15 × 10−10 10 75,562,161 343,524 37.50
rs73137144 A G 0.807 0.019 0.003 9.80 × 10−10 7 74,073,590 343,524 37.37
rs6686095 T G 0.811 0.019 0.003 1.02 × 10−9 1 93,883,993 343,524 37.29
rs3746778 G A 0.580 0.015 0.002 1.03 × 10−9 20 61,341,472 343,524 37.27
rs117211511 A G 0.044 0.036 0.006 1.07 × 10−9 12 121,701,433 343,524 37.19
rs1223801 G A 0.163 0.020 0.003 1.11 × 10−9 1 214,348,141 343,524 37.13
rs13062093 G T 0.366 0.015 0.002 1.44 × 10−9 3 35,667,057 343,524 36.62
rs1800973 A C 0.061 0.030 0.005 1.85 × 10−9 12 69,744,014 343,524 36.13
rs28472312 T C 0.704 0.016 0.003 1.98 × 10−9 16 28,826,049 343,524 36.00
rs12992995 C A 0.724 0.016 0.003 3.44 × 10−9 2 175,197,545 343,524 34.92
rs62104180 G A 0.950 0.032 0.005 3.87 × 10−9 2 466,003 343,524 34.69
rs114414824 T C 0.959 0.036 0.006 4.01 × 10−9 2 113,995,296 343,524 34.62
rs12516176 C T 0.274 0.016 0.003 4.17 × 10−9 5 150,435,645 343,524 34.55
rs11693537 A G 0.419 0.014 0.002 4.21 × 10−9 2 102,541,080 343,524 34.53
rs11708067 G A 0.246 0.016 0.003 4.41 × 10−9 3 123,065,778 343,524 34.44
rs76040012 T C 0.898 0.023 0.004 4.44 × 10−9 2 59,150,981 343,524 34.42
rs2030291 A T 0.612 0.014 0.002 4.66 × 10−9 11 16,251,251 343,524 34.33
rs2166625 G C 0.628 0.014 0.002 5.84 × 10−9 13 42,584,871 343,524 33.89
rs75064168 A G 0.091 0.024 0.004 6.22 × 10−9 3 101,845,939 343,524 33.76
rs4006577 G A 0.379 0.014 0.002 6.54 × 10−9 1 236,301,301 343,524 33.67
rs72636674 C G 0.166 0.019 0.003 7.04 × 10−9 4 67,998,903 343,524 33.53
rs17308476 T C 0.111 0.022 0.004 7.11 × 10−9 2 174,868,755 343,524 33.51
rs7833554 T C 0.555 0.014 0.002 7.26 × 10−9 8 103,642,986 343,524 33.47
rs7250946 T C 0.044 0.034 0.006 7.65 × 10−9 19 45,140,020 343,524 33.36
rs1580300 T A 0.197 0.017 0.003 8.02 × 10−9 12 21,701,150 343,524 33.27
rs9838974 A G 0.410 0.014 0.002 9.49 × 10−9 3 136,987,413 343,524 32.94
rs2432195 T C 0.827 0.018 0.003 9.68 × 10−9 5 56,120,413 343,524 32.91
rs12620844 C T 0.431 0.014 0.002 1.08 × 10−8 2 232,324,510 343,524 32.70
rs654912 T C 0.308 0.015 0.003 1.10 × 10−8 6 138,185,422 343,524 32.66
rs4148155 A G 0.886 0.021 0.004 1.42 × 10−8 4 89,054,667 343,524 32.16
rs3125326 C A 0.609 0.014 0.002 1.45 × 10−8 10 63,053,788 343,524 32.13
rs7317323 C T 0.057 0.029 0.005 1.52 × 10−8 13 42,957,489 343,524 32.03
rs12992747 A C 0.228 0.016 0.003 1.66 × 10−8 2 178,190,491 343,524 31.86
rs889745 T G 0.524 0.014 0.002 1.67 × 10−8 16 79,042,774 343,524 31.85
rs1859726 C T 0.093 0.023 0.004 1.66 × 10−8 1 44,396,215 343,524 31.85
rs9964912 A G 0.571 0.014 0.002 1.79 × 10−8 18 13,002,309 343,524 31.71
rs150649461 C G 0.015 0.056 0.010 1.94 × 10−8 1 92,925,654 343,524 31.55
rs34761529 C T 0.795 0.017 0.003 2.20 × 10−8 1 22,681,214 343,524 31.31
rs11617494 A G 0.241 0.016 0.003 2.23 × 10−8 13 110,383,798 343,524 31.28
rs2608101 C T 0.701 0.015 0.003 2.35 × 10−8 5 170,516,570 343,524 31.19
rs80292319 T C 0.941 0.028 0.005 3.03 × 10−8 15 76,508,632 343,524 30.69
rs141179989 C T 0.983 0.055 0.010 3.13 × 10−8 16 51,067,084 343,524 30.63
rs6845703 A G 0.662 0.014 0.003 3.50 × 10−8 4 45,134,713 343,524 30.41
rs35816944 A G 0.007 0.081 0.015 3.54 × 10−8 16 1,828,030 343,524 30.39
rs2172131 T C 0.420 0.013 0.002 3.66 × 10−8 10 133,978,962 343,524 30.33
rs7537072 T C 0.584 0.013 0.002 3.78 × 10−8 1 21,434,533 343,524 30.26
rs172305 G A 0.687 0.014 0.003 3.91 × 10−8 5 107,316,915 343,524 30.19
rs62618693 C T 0.955 0.031 0.006 3.94 × 10−8 11 32,956,492 343,524 30.18
rs2011689 A G 0.389 0.013 0.002 4.06 × 10−8 8 64,341,554 343,524 30.12
rs746839 G C 0.377 0.014 0.003 4.44 × 10−8 8 142,617,261 343,524 29.95
rs7485554 A G 0.572 0.014 0.002 4.63 × 10−8 12 84,070,366 343,524 29.87
rs62129471 A G 0.658 0.014 0.003 4.87 × 10−8 19 1,950,864 343,524 29.77

Abbreviations: rs ID—SNP; effect allele—EA; other allele—OA; effect allele frequency—EAF; effect—beta; standard error—SE; p-value—p; chromosome—CHR; position—POS; F-statistics calculated using Bowden’s method—Fstats.