Table 2.
Sensitivity analyses of the two-sample Mendelian randomization study between C-reactive protein and CVD outcomes using Approach 1.
| CVD Outcomes | Intercept (SE) | Pleiotropy p | Cochran’s Q | Q_df | Het p |
|---|---|---|---|---|---|
| Myocardial Infarction | 0.005 (0.003) | 0.055 | 295.11 | 176 | 4.67 × 10−8 |
| Coronary Artery Disease | 0.006 (0.002) | 0.005 | 500.58 | 169 | 1.54 × 10−34 |
| Heart Failure | 0.005 (0.002) | 0.024 | 241.40 | 176 | 7.81 × 10−4 |
| Atherosclerosis | 0.004 (0.003) | 0.253 | 283.14 | 176 | 5.37 × 10−7 |
| Hypertensive Heart Disease | 0.003 (0.004) | 0.404 | 225.15 | 176 | 0.007 |
Abbreviations: number of SNPs in the outcome—CRP-associated SNPs; MR-Egger intercept (standard error)—Intercept (SE); p-value for the MR-Egger intercept—Pleiotropy p; p-value for the heterogeneity tests performed using the MR-Egger method—Het p.