Table 4.
Sensitivity analyses of the two-sample Mendelian randomization study between C-reactive protein and CVD outcomes using Approach 2.
| CVD Outcomes | Intercept (SE) | Pleiotropy p | Cochran’s Q | Q_df | Het p |
|---|---|---|---|---|---|
| Myocardial Infarction | 0.004 (0.003) | 0.199 | 196.59 | 134 | 3.49 × 10−4 |
| Coronary Artery Disease | 0.001 (0.002) | 0.614 | 261.53 | 131 | 1.01 × 10−10 |
| Heart Failure | 0.007 (0.003) | 0.010 | 177.88 | 134 | 0.007 |
| Atherosclerosis | 0.006 (0.004) | 0.068 | 180.76 | 134 | 0.004 |
| Hypertensive Heart Disease | 0.007 (0.004) | 0.123 | 161.67 | 134 | 0.052 |
Abbreviations: number of SNPs in the outcome—CRP-associated SNPs; MR-Egger intercept (standard error)—Intercept (SE); p-value for the MR-Egger intercept—Pleiotropy p; p-value for the heterogeneity tests performed using the MR-Egger method—Het p.